ID A0A4D9DSE1_9SAUR Unreviewed; 1996 AA.
AC A0A4D9DSE1;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 12 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DR999_PMT20381 {ECO:0000313|EMBL:TFJ97753.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFJ97753.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFJ97753.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ97753.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ97753.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFJ97753.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ97753.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ97753.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFJ97753.1}.
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DR EMBL; QXTE01000463; TFJ97753.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9DSE1; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00116; LRR_RI; 2.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF05729; NACHT; 2.
DR Pfam; PF17776; NLRC4_HD2; 2.
DR Pfam; PF17779; NOD2_WH; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 20.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000297703}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 181..386
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1157..1355
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1996 AA; 226556 MW; 9A18C5B1208D8EF8 CRC64;
MENRSSRIND LLIHALNNLS QEEFKGFKDK LSHSDFKGKG NIPRGRLENA DAIDTKNLLM
AFYGGDAAVD VTIKVFSQIN LREAAANLRE ERENDYRVKY REHIQNKYRV IKDLNSRLGE
NVTLNSRYTK LIIVKKHCHK KEREHEIMTL GWRHEEIMTK RASSITLGNL FKCYEDGQTP
QIVVLLGAAG IGKTMTARKI MFDWAAGELY KEKFDYAFYI NCREVNFGSE EGRIADLILK
NCPNKNAPVE EILINPEKLL FIIDGFDELR FSLDQPEDNL CSDPCDKQPM EITLSSLVRK
TVLLESYVII TTRPTALEKL RQCLECARYA EILGFSAAER EEYFHKFFGN EEKARKAFNF
VKENEMLFTL CFVPIACWII CTVLKQQMEA GEDLAQTSKT ITGVYMLYLF SLLKGHSSNS
KKHTPANLKG LCSLAADGIW RQKILFGEEE IKKHGLDISD SLFLNENMFQ KDIDCECVYS
FIHLSFQEFF AALFYVLEKE ETTTVEDSET AMNNVKKLLE NYGKSRNYLM LTVRFLFGLL
NEERMEDMEK KLSCKISPKI KPDLLQWVKT KPKISSLSLE SEELFLEPDE ELSSFKRNAE
MIYQLEEFHC LYEIQEESFV QSALNRFTEL YLAEYNFTKM DQVALSFCLK NCRKLETLYL
NLCTFGFEDP NEDSLRPPKQ PRLEQHQDEP TCSPIYLFCQ ALKDPNCKLK KLKLTNGHLT
DACYRDLSAA LSTKQTLTEL DLSMNNLGDS GVRLLCEGLN HPTCKLQKLG LMGCQLTAAC
CEDLSSVLSI NQTLTELELR GNLLRDSGVQ LLCEGLKHAN CKLQKLGLKN FLLTDACCED
LAAVLSISDS LTELELGIDY LRDSGVQLLC EGLKHPNCKL QKLGLWGCDL TADCCGDLSS
ALSTSQYLTE LELGYNELGD AGVQLLCEGV KHPNCKLQKL GLEHCSLTAA CCGDLSSALS
MNQHLTELDI GRNKLADPGV QLLCQGLKHP NCKLHKISLG YQNVTEETQA ELDAVKDTQP
DLVIEIWIDT KNLLMKFYGG EAAVDVTIDV FTQIDLRDSA AKLREGKEKG YRKKYKEDVK
NKYEVIQSMT SLTTDNGILN RRYPKMIILD DPHHAKEREH EIMAMSWRDK EIKTKQVCSV
VTIDTLFTRD KQGQTPQVVV LLGAAGIGKT MTARKILYDW AAGELYNKKF DYIFYINCRE
TNLIEQGSVV DMIFKNWPNT NAPVSEILMK PEKLLFIIDG FDELRFSFDQ TENLCSDPWE
KKPVEIILSS LFRKTILPQS YLLITSRPTA LEKLLQCLGC SRYAEILGFS EADRKEYFHK
FFGNKKQARK ALQFVKANDI LFTMCFIPIM CWIICTVVKQ HLEKDEDLAQ TSKSVTGVYM
LYLSSLVKPL SSNLKQHMQA NLRGLCSLAA YGIWKQKILF EEAELKKFGL NQADSFPLSS
NKNIFQKDTD CVNAYSFIHL SFQEFFAALF YVLEEDEETM EDSGTPKKDV KTLLENYGNS
RNYLMLTVRF LFGLLNEERM HIMEETFSCK ISPKIKPDLL KWVQTNQQKY LPLSNVHQET
CHIYNLEEFH CMFEMYEENF VKSALDHFTA LTLDSNKLTQ MDQMAFSFCV KHCHRLESLC
ISYCTFAFGD HGEDVLPRRQ KWLYQIQHWH EPKHSPIYLL CQVLKDPNCK LKKLELVNCS
LTAACCRDLS SVLSTKPTLT ELDLSDKVLG NSGIKLLCEG LKHPNCKVQK LRLQYCCITG
AACGDLAAVL RTNQSLTELN LNGNPLGASG VQRLCEGLKH PSCKLQRLWL EGCHLKDTCG
RDLAAVLRAK QSLTELEMCH NYDLRDTAVK LLCEGLKHPN CKLQRLILNS CNLTDACCGA
LSSVLSTSQT LTELVLGYNK VGDPGVQLLC EGLKQPNCTL QILNLCLCEL TAACCGDLAS
ALSTNQTLTE LNIGGHSLGA SGVQRLCEGL KHPNCKLQKL GLWSYDIIAD LNAGDSRAMV
LCGGLRFVSC DLRNFL
//
