ID A0A4D9DSU3_9SAUR Unreviewed; 756 AA.
AC A0A4D9DSU3;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 03-MAY-2023, entry version 13.
DE SubName: Full=Ryanodine receptor 1 {ECO:0000313|EMBL:TFJ99431.1};
GN ORFNames=DR999_PMT18525 {ECO:0000313|EMBL:TFJ99431.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFJ99431.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFJ99431.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ99431.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ99431.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFJ99431.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ99431.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ99431.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFJ99431.1}.
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DR EMBL; QXTE01000329; TFJ99431.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DSU3; -.
DR STRING; 55544.A0A4D9DSU3; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:TFJ99431.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 348..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 402..659
FT /note="Ryanodine Receptor TM 4-6"
FT /evidence="ECO:0000259|Pfam:PF06459"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..296
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 85000 MW; 0D13EB1D185D279B CRC64;
MVRIGGQREK RISQKRNPTI ETSRPAAPQR RDSSQIGLLK ELLDLQKDMV VMLLSLLEGN
VVNGTIARQM VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFLDYITDP RGLISKKDFQ
KAMDSQKQYT PSEIQFLLSC SEADENEMIN YEEFANRFQE PAKDIGFNVA VLLTNLSEHV
PHDSRLKTFL ELAESILNYF RPYLGRIEIM GASKRIERIY FEISETNKAQ WEMPQVKESK
RQFIFDVVNE GGESEKMELF VNFCEDTIFE MQIASQISEE EAGKEEEEEE EGEGGEGTEA
EKAAGAPPEA TSAFGEFLAG VLDFFHMFTY RNLRRQLRRL KKMTVKELAV GVSSCIYAVL
LGTLLFFSGV LKGFLLLLWN VLFGGGLVEG AKKLTVTELL ASMPDPTQDE VHGDLGPAED
GQEAAEGGDA AQFVEAGKEE APDEAGEVFS MEMKKDTGHY RATAPDAPGG LGDMGDSTAL
EGEEEAQPEP EKIEEPPVEA EKADTENGEK AGPEEPEAPQ EPAAEAPRKH RRKSAAPREH
KEEPADGTLE FWAELEIQRV KFLNYLSRNF YNLRFLALFL AFAINFILLF YKELAGGSGF
GASGDGAGED EEEDSVVYFF LEESTGYMQP TLQFLSITHT LVAFLCIIGY NCLKVPLVIF
KREKELARKL EFDGLYITDQ PEDDDIKGQW DRLVLNTPSF PSNYWDKFVK RKVLDKYGDI
YGRERIAELL GMDLASLEIS AQSERKPQPD KSLLTW
//
