ID A0A4D9DU11_9SAUR Unreviewed; 1812 AA.
AC A0A4D9DU11;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN ORFNames=DR999_PMT17204 {ECO:0000313|EMBL:TFK00669.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK00669.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK00669.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK00669.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK00669.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK00669.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK00669.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK00669.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK00669.1}.
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DR EMBL; QXTE01000261; TFK00669.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9DU11; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 58..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1141..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1346..1369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1503..1536
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 292
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 602
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1002
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1812 AA; 205678 MW; 0A1623ECE683A68A CRC64;
MEPASAQDDQ KKKQQKEKSK KPVPPAAPRP ARALFCLTLQ HPLRKACIGI VEWKPFEIII
LMTIFANCVA LAVYLPMPKD DTNASNSSLE KIEYVFLIIF TIEATLKIIA YGFLLHTDAY
LRNGWNVLDF AIVSLGLVTV VVEQINMMQG APLTGKGGFD VKALRAFRVL RPLRLVSGVP
SLQVVLNSII KAMVPLFHIA LLVLFMIIIY AIVGQELFKG KMHKTCYYIG TDVIAIGEME
KPSPCASTGH GHHCTLNGTE CRSGWPGPNH GITHFDNFGF AMLTVYQCIT MEGWTEVLYW
VNDAIGNEWP WIYFVSLILL GSFFVLNLVL GVLSGEFTKE REKAKSRGTF QKLREKQQLE
EDLKGYMDWI THAEVMDSHR ARGEGMLPSE EGGSETESLR QWRRWNRLFR RKCREVVKSK
FFYWLVILLI SLNTLSIASE HHWQPEWLTR VQDSANRVLL ALFAAEMLLK MYALGLRQYF
MSLFNRFDCF VVCVGIVEVI LVEINVMSPL GISVLRCIRL LRIFKITRYW TSLSNLVASL
LNSVRSIASL LLLLFLFIII FSLLGMQLFG GKYDFEDVEV RRSTFDNFPQ ALISVFQILT
GEDWNSIMYN GIMAYGGPSF PGVLVCIYFI ILFVCGNYIL LNVFLAIAVD NLAEAESLTS
AQKAKAEEKK RRKMSRSYPE KSEEEKLLLA KKLEQKAKAE GIPTTAKLKV DEFESNVNEI
KDPYPSADCP GDDEEDEPEI PLSPRPRPLA ELQLKEKAVP MPEASAFFIF SPTNKIRALC
HRIVNATWFT NFILLFILLS SVSLAAEDPI RPESFRNKIL GYFDIGFTSV FTVEIVLKMT
AYGAFLHKGS FCRNYFNILD LLVVAVSLIS MGIESSTISV VKILRVLRVL RPLRAINRAK
GLKHVVQCVF VAIKTIGNIV IVTTLLQFMF ACIGVQLFKG KFSSCTDLAK MTEKECRGYF
IIYKDGSATQ PELYRREWVH NDFHFDNVLS AMMSLFTVST FEGWPQLLYK AIDTHTEDMG
PIYNYRVEIA IFFIIYIILI AFFMMNIFVG FVIVTFQEQG ESEYKNCELD KNQRQCVQYA
LKARPLRRYI PKNPYQYQIW YVVTSYYFEY LMFFLIMLNT ICLGMQHYNQ SAEMNYISDN
LNVAFTILFT LEMFLKLMAF KAKGYFSDPW NVFDFLIVIG SIIDVILSEI DTFLASSGGL
YCLSGGCSGI DSADNTRVSI TFFRLFRVMR LVKLLSRGEG VRTLLWTFIK SFQALPYVAL
LIVMLFFIYA VIGMQMFGKI ALVDGTQINR NNNFQTFPQA VLLLFRCATG EAWQEILLAC
SYGKKCDPES DFAPGEEYTC GTGFAYFYFI SFYMLCAFLI INLFVAVIMD NFDYLTRDWS
ILGPHHLDEF KRIWAEYDPE AKGRIKHLDV VTLLRRIQPP LGFGKFCPHR VACKRLVCMN
MPLNSDGTVT FNATLFALVR TALKIKTEGN FEQANEELRA IIKKIWKRTS MKLLDQVIPP
IGEDEVTVGK FYATFLIQEH FRKFMKRQEE YYGYRPKKNA IAIQAGLRSI EEEAAPEIHR
AISGDLTAEE ELERAMMEAA IEEGIYRRTG GLFGHADSFL ERNSPLQPHV TSQRPLQFTE
VGSEDLDSPV FLDDFPPDRN TNANNSNTAA WVQYEDELRG ERMLPASCQP QPHSALGHNR
SFRLEKQQRR LDRKRAASVG RCPGLELQLP REEAAAREQG AELSSECQLD GGSDANGEGD
AAASTPATTL LIQEALLSRG LGALARDLSF VTAMRAEVAA TCQLEMMLME EAAAELLRGR
ESPEGAEAGS TR
//
