ID A0A4D9DU57_9SAUR Unreviewed; 215 AA.
AC A0A4D9DU57;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
GN ORFNames=DR999_PMT16612 {ECO:0000313|EMBL:TFK01231.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK01231.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK01231.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01231.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01231.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK01231.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01231.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01231.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC leukemic cells. Its activities include the induction of hematopoietic
CC differentiation in normal and myeloid leukemia cells, the induction of
CC neuronal cell differentiation, and the stimulation of acute-phase
CC protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK01231.1}.
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DR EMBL; QXTE01000236; TFK01231.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DU57; -.
DR STRING; 55544.A0A4D9DU57; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003624; Leukemia_IF.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR PRINTS; PR01883; LEUKAEMIAIF.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703}.
FT REGION 187..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..215
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 23943 MW; EC73D6FCC66FDB3D CRC64;
MMEAVTQGLF IQCLARVNSS TAPCRGCHRN SLGKITAKTR QMEKEAKELF RSYLTHQGLL
TSDLRRLCDE AVPWFPTENI TDQPKVVMLQ ELYRTLVHTK DALENIRKQQ QVLSTPGAAL
LGKLQSTQWA VRGLLSNTGC ALCLKGVSPN SRHTPERPAA TNAFQQKIDG CKVLGNYSKF
LEKLARGLGK KAPQALRDQR KRRKGTKRKG GSSHS
//
