ID A0A4D9DVY4_9SAUR Unreviewed; 389 AA.
AC A0A4D9DVY4;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Peptidyl-prolyl cis-trans isomerase A {ECO:0000313|EMBL:TFJ98793.1};
GN ORFNames=DR999_PMT19249 {ECO:0000313|EMBL:TFJ98793.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFJ98793.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFJ98793.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98793.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98793.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFJ98793.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98793.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98793.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFJ98793.1}.
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DR EMBL; QXTE01000367; TFJ98793.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DVY4; -.
DR STRING; 55544.A0A4D9DVY4; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Isomerase {ECO:0000313|EMBL:TFJ98793.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 237..332
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 327..376
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 43644 MW; 8A4ECEEBC4D99CB5 CRC64;
MSQAAEGPDR GARPKERSGE AGGRRSGRRR AKLPETPAGQ DSEGAEPGRR AGRSLRQRIQ
DAVGQCFPIK GPGGARSPEF SPSQRKIHLR ELMLETCPFP AGSELARKWN LIKQHTAPVT
AQEGLACGGA APAEDEDDRL RERRRISIEQ GVEPPPDAMI HTFEATAQIN PLYKLGPKLA
PGMNELAGDN RATLAPQEEE EEEPVTAAPE PELRVHTQID YIHCLVPDLL QLTRLPCYWG
VMDRYQAEAL LEGKPEGTFL LRDSAQEDYL FSVSFRRYGR SLHARVEQWN HNFSFDVHDP
GVFHAPTVSG LLERYKDPSA CMFFEPLLSR PVRRPFPFAL QHLCRAVVAG CTSYDGIGRL
PIPGALQEYL KEYHYKQKVR VRRLDARWN
//
