ID A0A4D9DXQ0_9SAUR Unreviewed; 474 AA.
AC A0A4D9DXQ0;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361, ECO:0000256|PIRNR:PIRNR037403};
GN ORFNames=DR999_PMT14785 {ECO:0000313|EMBL:TFK02851.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK02851.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK02851.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02851.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02851.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK02851.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02851.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02851.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037403,
CC ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK02851.1}.
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DR EMBL; QXTE01000172; TFK02851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DXQ0; -.
DR STRING; 55544.A0A4D9DXQ0; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19394; TGF_beta_GDF10; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Cytokine {ECO:0000256|PIRNR:PIRNR037403};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037403};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037403};
KW Signal {ECO:0000256|PIRNR:PIRNR037403}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR037403"
FT CHAIN 24..474
FT /note="Bone morphogenetic protein 3"
FT /evidence="ECO:0000256|PIRNR:PIRNR037403"
FT /id="PRO_5019883196"
FT DOMAIN 362..474
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 44..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 372..439
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 401..471
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 405..473
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 438
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 474 AA; 53350 MW; 22EA4B0342DFDE77 CRC64;
MAGSPRSLLC LCLGWSCLCL ALGDLLRAHL VGLRRKAALG GVTGGRARAA GDPGPAPQQL
PPGDKVSEHM LRLYDKYSGA RRQELPSLHP LHLREGNTVR SFRALPAGSP GSKEPHVFNL
TSLTKSENIL SASLHYYIGD LLNATWSCPQ SGGCSRHGHR KPEIQIDLSV LSFPSDGNQT
RTLGRFLINV SMAYRDVLSW QWKDITHVLS EAKQNDELLI GVKMALTGRY SWRRMLSCYE
PYILVYANDS AISEPESVVS SLQGHRNSLV EGFPRLESHS KSSLGEQRRK RSTNILLPLQ
NNELPGAEYQ YNEDDGWEDR KPYKTLQPRL AERTKGKKKQ RKNNHQKSQT LQFDEQTLKK
ARRKQWNEPR YCARRYLKVD FADIGWSEWI ISPKSFDAYY CSGECQFPIP KVLKPSNHAT
IQSIVRAVGV IPGIPEPCCV PDKMSSLSIL FFDENKNVVL KVYPNMTVES CACR
//
