ID A0A4D9DZ53_9SAUR Unreviewed; 393 AA.
AC A0A4D9DZ53;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 22-FEB-2023, entry version 10.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
GN ORFNames=DR999_PMT15950 {ECO:0000313|EMBL:TFK01795.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK01795.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK01795.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01795.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01795.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK01795.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01795.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01795.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK01795.1}.
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DR EMBL; QXTE01000210; TFK01795.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DZ53; -.
DR STRING; 55544.A0A4D9DZ53; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000297703}.
SQ SEQUENCE 393 AA; 43781 MW; 554E22E9DD465044 CRC64;
MDSAAASASP VLAAEAAQRP PHMAALVLAR GGSKGIPRKN IKRLAGLPLI GWVLRAAIDS
KVFQSVWVST DHDEIEKVAK EFGAQVHRRS AKVSKDSSTS LEAIQEFLCR HNEVDIIGNI
QATSPCLHPD DLIKVAKMIR EDGYDSVFSV VRRHLFRWSE IKKGVNEVTI PQNLNPAKRP
RRQDWVGELY ENGSFYFAKK DLIEKGYLQG GKMTYYEMRA EHSVDIDVDI DWPIAEQRVL
RYGYFGKELK EVKLLVCSIA VCLTNGHNNG CLSEDQKEII SDDNRGADGI ALLKERGVQV
RRISEEDCSK MTQRQVVENW RNEMSLSWRE VAYLGYEESD VDCLKEAGMS GVPADACAAA
QKAAGYICKS NGGCGAIQEF AKYILPLMKT VNL
//
