ID A0A4D9E053_9SAUR Unreviewed; 1110 AA.
AC A0A4D9E053;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Rhomboid domain-containing protein 3 {ECO:0000313|EMBL:TFK02487.1};
GN ORFNames=DR999_PMT15164 {ECO:0000313|EMBL:TFK02487.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK02487.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK02487.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02487.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02487.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK02487.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02487.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02487.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK02487.1}.
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DR EMBL; QXTE01000187; TFK02487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9E053; -.
DR STRING; 55544.A0A4D9E053; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR CDD; cd14028; STKc_Bub1_vert; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 6.10.130.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000297703}.
FT DOMAIN 1..164
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 810..1110
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 149..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 272..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 149..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 844
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1110 AA; 123887 MW; F1FBCD1504F408B2 CRC64;
MENPPSEVDT LWDARSGKGP AVLQVAAEGA QEIPAMGGKC LPASGRTGTL VRFIRAACES
VHQSGEAEFI SAPSQFFDYI YSQGVGTRTS ALYIAWAQQL ETEGNIQHAG AVLQKGIHNQ
AEPMENLQEQ YRLFQSRIPR SHPLTQVAAS KQLHNSQTPN QMAPRKDVSE SGDPACLSKS
QDPTLSAAQS SQDGAGKVEY LTYISKSAVL PKLSSTSNEF EQVAMYNKSM LICEGSELSF
EEVRAKIVYR KQERLRRQKE WEEEERNYAK RKESAILEMQ CLQQKLEQLS QLTKDYPEAK
LEEGSMLQSV PDRMVVDPCV KPSPALQHDW TAPSQMTNLQ TSWCLGPDQL QSRAAASTST
ADTSVPKPVE AASHQSVSAS LSMVTYEKVT GEAKLDLGEL RNTLSQLELK SGDAVSQPIQ
EHSTFSHGHS AGQQHSNVST PGLKLDHCTA MKEAPRMGNA SVSFGNASQA TPNTSLGGVM
QATPFKVQPS PTVHTKEALG FLMDMFQTPI LPEMPSLQEN EEKFEAYCRK SEPGKSMKAN
DTAPVVSAFS IFEDENEKEN NRFPQQKNKL AQARAFGEHP LLRCAEQSKE GTRTTEFLMD
DSTVWALQCN NKTLAPSPNS TRDFARATQL ASTPFNYLSA HSWQPMEDKE NAVHNNDGKM
VLDSSEEQYM EVSKTRKLSP VLEQSPEQGS LPGNAHSAAA SLVLNQQLAT EKAVLETLQA
ARGYSHEETV LTACKESVST PQILVCTEDR TYQNVKTPVI VENPWDEGLI RTLLSRLPKP
LSTYSNTFEW KSSLPTIKLK TELTLGPKSF HVDCLLGEGA FAHVYQASVL DTNNPKNNQK
VILKVQKPAS PWEFYIASQL MERLKPSVRH LYIQFYSAHF FQNGSILVGE LYNYGTLLNT
INIYKKLPEK VMPQALVIYF AVKILYMVEE LHNCGIIHGD IKPDNFILGE RLLDNDTCDI
DSLSHGLTVI DLGQSIDLKL FPEGTAFIGK CETSGFQCIE MLTRKPWNYQ TDYFGIAGTI
YCMLFGTYMR VRNEEGIWKT KGVFRRIPNA ELWNEFFCSL LNIPDCHHLP SLGALRKKLR
DLFQKSYAKE IKFLRNRLVV LLIENKRSRK
//
