ID A0A4D9E0H3_9SAUR Unreviewed; 449 AA.
AC A0A4D9E0H3;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=AP-4 complex subunit epsilon {ECO:0000256|PIRNR:PIRNR037097};
GN ORFNames=DR999_PMT14963 {ECO:0000313|EMBL:TFK02677.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK02677.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK02677.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02677.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02677.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK02677.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK02677.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK02677.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: AP-4 forms a non clathrin-associated coat on vesicles
CC departing the trans-Golgi network (TGN) and may be involved in the
CC targeting of proteins from the trans-Golgi network (TGN) to the
CC endosomal-lysosomal system. {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC of two large adaptins, a medium adaptin and a small adaptin.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK02677.1}.
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DR EMBL; QXTE01000179; TFK02677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9E0H3; -.
DR STRING; 55544.A0A4D9E0H3; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0030124; C:AP-4 adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017109; AP4_complex_esu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF13; AP-4 COMPLEX SUBUNIT EPSILON-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF037097; AP4_complex_epsilon; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037097};
KW Membrane {ECO:0000256|PIRNR:PIRNR037097};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037097};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Ribonucleoprotein {ECO:0000313|EMBL:TFK02677.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037097}.
FT DOMAIN 54..443
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
SQ SEQUENCE 449 AA; 50676 MW; 1FAE82EFD908C929 CRC64;
MSDVVERTLS ALPGLLGQQD PGSGPGGGPG RVSATSRLGG LIRSITALSS KHEEEKLIQQ
EQTNLKATVS APTTTLRLMK ECMVRLIYCE MLGYESSFGY IHAIKLAQQG NLLEKRVGYL
AVSLFLHENH ELLLLLVNTV VKDLQSTNLV EVCMALTVVS QIFPREMIPA VLPLIEDKLQ
HSKEIIRRKA VQALYKFYLI APNQVQHIHD KFRKALCDRD VGVMAASLHI YLQMIKKNAS
GYKDLTESFV TILKQVVGGK LPIDFNYHSV PAPWLQIQLL RILGLLGKDD PRTSELMYDV
LDESLRRAEI NHNITYAILF ECVQTIYTIC PKSDLLEKAA KCIGKFVRSP KINLKYLGLK
ALTYVIQQDP NLALQHQMTI IECLDHPDPI IKRETLELLY RITNGQNVTV IVQKMLDYLR
QSKEEYTIIN LTGKIAELAE KYPFLLLKI
//