ID A0A4D9E2E8_9SAUR Unreviewed; 447 AA.
AC A0A4D9E2E8;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Transcription factor {ECO:0000256|PIRNR:PIRNR009404};
GN ORFNames=DR999_PMT16648 {ECO:0000313|EMBL:TFK01150.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK01150.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK01150.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01150.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01150.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK01150.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK01150.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK01150.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK01150.1}.
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DR EMBL; QXTE01000238; TFK01150.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9E2E8; -.
DR STRING; 55544.A0A4D9E2E8; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR PANTHER; PTHR12548:SF5; TRANSCRIPTION FACTOR DP-2; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR PIRSF; PIRSF009404; Transcription_factor_DP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transcription {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 127..209
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 216..360
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 218..245
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 407..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 49129 MW; 5FBA5D81A72F6D1F CRC64;
MTAKNIGVTS TNGDLKGFID QNRSPSKGNF SVIALPVSST NSPAKILPKT LGPVNVNVGP
QMIISTPQRL TNSGSVLIGS PYTPAPAMVT QTHITEATGW IPGDRKRARE FIESDFSESK
RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNSHLA TDSQAYDQKN
IRRRVYDALN VLMAMNIISK EKKEIKWIGL PTNSAQECQN LEIEKQRRLE RIKQKRAQLQ
ELLLQQIAFK NLVQRNQQNE QQNQGPPALN STIQLPFLIV NTSKRTVIDC SISSDKFEYL
FNFDNTFEIH DDIEVLKRMG MSFGLEAGKC SAEDLRTAKS LVPKALESYV TDMATGLSWL
NQGLLLNSAH SVSTLETAGS TSISKSSGNP GLCLDAEVAL ATGQFLAPGS QQSSSATSRY
SESRGETPCS FNDEDDDDDD DDSSSPE
//
