ID A0A4D9E8I0_9SAUR Unreviewed; 1442 AA.
AC A0A4D9E8I0;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE SubName: Full=Leucine-rich repeat and fibronectin type-III domain-containing protein 5 {ECO:0000313|EMBL:TFK04785.1};
GN ORFNames=DR999_PMT12645 {ECO:0000313|EMBL:TFK04785.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK04785.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK04785.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK04785.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK04785.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK04785.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK04785.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK04785.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK04785.1}.
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DR EMBL; QXTE01000128; TFK04785.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9E8I0; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 883..1072
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1101..1195
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1234..1293
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1345..1441
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..861
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 161641 MW; 0D8D6E2D340A5C70 CRC64;
MSSAEIKKPP VAPKPKFVVG HKASPPPVAP KPDVVFAGVI QTTKKTKPAI APKPKVLKSS
SVPEVRPPSS LRKSTKSLEE HKGDSSETLD HLNYKNGDSA ESTEDTAYII PMCSCNFECI
HKLGNGESTC KTQIIFEHFE NLENIKIGEQ IAPSIKGRTI QESHSEKVAN RNRVVLKDSL
LEGTLKDVLT QSVFPNSSPL RHKCPDKLER DDSSSSNNEV KIEFTDLVQL SGSEEATGKP
QNNHNKRDAD EIHVSETCSS LTESNHNCYC SLDQETLENV NVNSDITLPG GVCMKGDDKT
PPSSGACSTP SSKVLPVPKP RKPRAACLVR QDGIDTSGEG TREPINSKSD SAGSSEHIFK
KTAKINVLGQ SVSYNDHPEK VHQTNTFEIP QNLAEKIHWV KESTDTEELA SQNILPQLLQ
EASLMTENVK RSLDEDLNFT SPADEMTDDA SILAAVDKRT SFIRSSTLSM SLPKQLKLTC
NQHLPASSSL DVSVQKPENK EIHVKDESSP RIVPKKPQRH SLPAAGLLKK AASEELVEKS
SYVSSEDKKS ESVLGRTHLR HMLAKEQGMS PYCDMPKRSS EKPVWKLPHP ILPFSGNPES
LKTATIATNS DLSTVVIKPR AKSLSSVDMD RTDKPSKDSQ KKNTLKKFLN IKLSVCIMKS
DFQKFFSKGS QSMDGAIASL PTGEGNGIGN NWNVTSLASE RKTKSAKARS AEIGSPASQK
KRQRHRSQHD IPNSQRLESL DEQIFSGKQL SQTHLNSLTS DYPPEYENVR HYEEIPEYEN
LPFIQSSDKN PCFEWQNSSS VVEDHDTNVY EVEEPYDATS SHSRHGRASE DHSDSNVLMG
EVQSDEEIIN SSDEDDDTNS DSSKGELDLQ EYKQSKAAGK KTKVYHIAKE IMSSEKVFVD
ALKLLHIDFR DAVAHASRQL GKPVIEDRIL NQILYYLPQL YELNRDLLRE LEERLSHWID
YQRIADIFVK KGPYLKMYST YIKEFDKNVA LLDEQCKKNP SFAAVVKDFQ MSPRCASLAL
KHYLLKPVQR IPQYRLLLTD YLKNLLEDSA DYRDTQGALA VVIEVANHAN DIMKQGDNFQ
KLMQIQYSLN GHHEIVQPGR VFLKEGTLMK LSRKVMQPRM FFLFNDALLY TTPVQSGMYK
LNNMLSLAGM KVRKPTQEAY QNELNIESVE RSFILSASSA TERDEWLEAI SRSIEDYTKK
RITFNPSKSL EEADPEKEDE DSPLGSKAPI WVPDTRATMC MICTSEFTLT WRRHHCRACG
KIVCQACSTN KHGLDYMKNQ PARVCDHCFK ELQKQDNHFT PKSGSPVNHK SPSSALSTVL
HSIPSGRKQK KIPAALKEVS ANTEDSSMSG YLYRSKGSKK PWKHLWFVIK NKVLYTYAAS
EDVAALESQP LLGFTVSEVK DENSESKVFH LLHKNTLFYI FKADDPHSAQ KWIEAFQEGT
IL
//