ID A0A4D9E9T4_9SAUR Unreviewed; 545 AA.
AC A0A4D9E9T4;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Protein quaking {ECO:0000313|EMBL:TFK07961.1};
GN ORFNames=DR999_PMT09162 {ECO:0000313|EMBL:TFK07961.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK07961.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK07961.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07961.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07961.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK07961.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07961.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07961.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK07961.1}.
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DR EMBL; QXTE01000075; TFK07961.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9E9T4; -.
DR STRING; 55544.A0A4D9E9T4; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR46876; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11; 1.
DR PANTHER; PTHR46876:SF1; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF07502; MANEC; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00765; MANEC; 1.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..545
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020023521"
FT TRANSMEM 496..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..147
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 388..438
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 165..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 280..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 287..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 299..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 545 AA; 58256 MW; 2AC9718FB048B647 CRC64;
MASRLLLLLA ALCGRAPGGE VAAPLAELRS QISGVESLLE EFRRQLQPDE AGRGSCRGGA
FSARPDAIIR TKDSLAAGAT FLRAPAAVAG WRQCLQACCA EPRCSLAVVQ RARPPGEPGA
LSCYLFNCTY RGRAVCRFAP HRGYSSYSLG PANLTQLLAH GPRGSPLPAL TQAAENDKPP
HSKAGQDIVL QSPVDWVILD GRESLDDHGI IQYEWTLLQG DSSVDIKVPQ PGTLKLSHLQ
EGVYIFQLTV TDTAGQKSSD NISVTVLPMV HSALGCTGVC SRYQFICDDG CCIDITFACD
GVEQCPDGSD EAFCQNFSPG RKTVTHAAIS TAQQRIVGLT KDADNSVENT QKNTIRNQPL
LSLDADKSNQ SLSQGPKKQI SGFIPEQCLV PPAAGPCKGH FPRWHFDISS GTCLHFIYGG
CKGNENNFLQ ESDCLSECVE IHGAISQQTA TDPSSQSNSE PANSSSGKRT GKNENGIVVS
KSDQAAGEHP VPETGAVLPL ALGLAITALL LLMVACRLRL VRQKLKKARP ITSEESDYLI
NGMYL
//
