ID A0A4D9EBC3_9SAUR Unreviewed; 289 AA.
AC A0A4D9EBC3;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=VIP peptide {ECO:0000313|EMBL:TFK07969.1};
GN ORFNames=DR999_PMT09171 {ECO:0000313|EMBL:TFK07969.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK07969.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK07969.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07969.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07969.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK07969.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07969.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07969.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC stimulates myocardial contractility, increases glycogenolysis and
CC relaxes the smooth muscle of trachea, stomach and gall bladder.
CC {ECO:0000256|ARBA:ARBA00002470}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK07969.1}.
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DR EMBL; QXTE01000075; TFK07969.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9EBC3; -.
DR STRING; 55544.A0A4D9EBC3; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF5; VIP PEPTIDES; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..240
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 21..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 289 AA; 32149 MW; D2498FB1A1B8E215 CRC64;
MYKPYKTRRF GGLSRVLLKG RDGISLRKRA GEHHRNSSPS HTDPAPTHSP SVPRTECGSS
SRGIQHLGEL PAPGGLPRRK DPASSSMMEH RSSSQLLLSF TLFSVLCSPA LALPPLGTYS
AMRLGNRMPF DGASAPDQAQ GSLKPETDIL QNALPENDKF YLDMSRAMDR NARHADGLFT
SGYSKLLGQL SARRYLESLI GKRVSNNLMD EQMPVKRHSD AVFTDNYSRF RKQMAVKKYL
NSVLTGKRSQ EELNPASLRD EAELLEPSFS ETYDDVTVDE LLNRLPLSL
//
