ID A0A4D9EDS3_9SAUR Unreviewed; 2539 AA.
AC A0A4D9EDS3;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
GN ORFNames=DR999_PMT08691 {ECO:0000313|EMBL:TFK08497.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK08497.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK08497.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08497.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK08497.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK08497.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08497.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK08497.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK08497.1}.
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DR EMBL; QXTE01000069; TFK08497.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9EDS3; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 30.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044:SF471; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 23.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 33.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 19.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 23.
DR PROSITE; PS00022; EGF_1; 34.
DR PROSITE; PS01186; EGF_2; 27.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2539
FT /note="Neurogenic locus notch homolog protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020025028"
FT TRANSMEM 1734..1755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..58
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 59..99
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 102..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 178..216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 412..450
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 452..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 490..526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 528..564
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 566..601
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 603..639
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..676
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..714
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..751
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 791..827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..867
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 869..905
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 907..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 983..1019
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1021..1057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1059..1095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1145..1181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1183..1219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1221..1265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1267..1305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1307..1346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1348..1384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1387..1426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1449..1489
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1490..1527
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1528..1571
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1927..1959
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1994..2026
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2027..2059
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2060..2092
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1778..1812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2454..2490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2498..2532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 432
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 435
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 452
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 453
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 469
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 470
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 490
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 491
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 493
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 507
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 508
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 48..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 89..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 206..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 245..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 381..398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 400..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 416..429
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 423..438
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 440..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 456..467
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 461..476
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 494..505
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 499..514
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 516..525
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 554..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 570..580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 591..600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 629..638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 645..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 704..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 720..730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 741..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 779..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 817..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 838..855
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 857..866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 895..904
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 933..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 971..980
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1009..1018
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1047..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1085..1094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1133..1142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1171..1180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1209..1218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1255..1264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1276..1293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1295..1304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1336..1345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1374..1383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1416..1425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2539 AA; 275597 MW; 1BAA8F5525C0DCF1 CRC64;
MQQLLVQSLL LSLLPVLSRG LRCTQPAESC LNGGKCETYS NGTGVCLCNS AHVGDRCQLP
NPCLSSPCKN AGTCHPVLRG NAVDYTCSCR LGFTDRLCLT PEENACLNNP CRNGGTCDLL
TLTEYKCRCP PGWSGKTCLQ ADPCASNPCA NGGQCVPFEA HYFCKCTAGF HGANCKQDIN
ECNASPPICK NGGSCTNEVG TYQCSCKPAY TGQNCEHLYV PCNPSPCQNG GTCRQTGDTT
YDCTCLPGFA GQNCEDNIDD CPGNNCKNGG TCVDGVNTYN CQCLPEWTGQ YCTEDVDECQ
LMPNACQNGG TCHNNHGGYN CVCVNGWTGE DCSENIDDCA MAACFQGATC HDRVASFYCE
CPHGRTGLLC HLDDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACN QDIDECSLGA
NPCEHAGKCI NTQGSFQCQC LQGYSGPRCE IDVNECLSNP CQNDATCLDQ IGEFQCICMP
GYEGVYCEIN TDECASSPCL HNGNCIDKIN EFHCECPTGF NGHLCQYDID ECASTPCKNG
AKCIDGPNTY TCECTEGFAG AHCEIDKDEC DPDPCHYGTC RDGVAAFTCL CQPGYTGHLC
EFNINECQSQ PCKNGGTCQD RDNAYNCLCL KGTTGPNCEI NLDDCASNPC DYGKCLDKIN
GYECTCEPGY TGRMCNINID ECAGNPCHNG GTCKDGINGF TCICPEGYHD PMCVLEVNEC
NSNPCIHGKC NDGLNGYRCD CDPGWSGTNC DINNNECESN PCMNGGTCKD MTSGYICTCR
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGATCEDVL APCAAGPCKN
GGECRESEDY ESFSCVCPSG WQGQTCEIDI NECVKSPCRN GATCQNTDGN YRCNCKAGYT
GHNCDTDIDD CKPNPCHNGG SCSDSINAFF CDCLAGFRGP KCEEDINECA SNPCKNGANC
TDCVNSYTCT CPSGFSGIHC ENNTPDCTES SCFNGGTCVD GINTFTCVCP PGFTGSYCEH
DINECDSKPC LNGGTCQDSY GTYKCACPQG YTGLNCQNLV RWCDSSPCKN GGKCWQTNNL
YRCECNSGWT GLYCDVPSVS CDVAAKQQGV DMMHLCRNSG LCVDTGTTHF CRCQAGYTGS
YCEEQVDECS PNPCQNGATC TDYLGGYSCE CVAGYHGVNC SEEINECLSH PCQNGGTCID
LINTYKCSCP RGTQGVHCEI NVDDCSPFFD PVTLGPKCFN NGKCTDRVGG YSCICPPGFV
GERCEGDVNE CLSNPCDARG TQNCVQRVND YKCECRQGYA GRRCDTVVDG CKGKPCRNGG
TCAVASNTGR GFICKCPPDF DGATCENDSR TCGNLRCLNG GTCISSHKSS KCICDPAFTG
PDCQYPISSP CHSNQCYNGG TCEYFSDAPP YFRCKCPANF NGLYCHILDF DFRGGIGRDI
PPPTIEEKCE IPDCAGFAGN KICDAKCNNH SCGWDGGDCS LNFNDPWKNC SQSLECWKYF
NNERCDKQCN NSGCLYDGFD CQKVEGQCNP LYDQYCKDHF SDGHCDQGCN NAECEWDGLD
CANNMPEKLA DGTLVVVVLI TPENLKNNSF NFLRELSRVL HTNVVFKKNP KGEYMIFPYY
GNEEELKKHH IKRSTENWSD MPSAVFNTIK TSLSSHVGER QRRELDQMDI RGSIVYLEID
NRQCIQSSSQ CFQSATDVAA FLGALASLGN LNIPYKIEAV KSETAEPQRN SQLYPMYVVV
AALVLLAFIG VGVVVSRKRR REHGQLWFPE GFKVTESSKK KRREPLGEDS VGLKPLKNAS
DGTLMDDNQN EWGDEETLDT KKFRFEEQAM LPDMDDQTDH RQWTQQHLDA ADLRISSMAP
TPPQGEIDAD CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL
HNQTDRTGET ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL
IRNRATDLDA RMHDGTTPLI LAARLAVEGM LEDLINCHAD VNAVDDLGKS ALHWAAAVNN
VEAAMVLLKN GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI
AQERMHHDIV RLLDEYNLVR SPPLHNGPLG APTLSPPLCS PNSYIGNLKP NIQGKKARKP
STKGLSCNSK DSKDIKARRK KSQDGKGCLL DSSSVLSPVD SLESPHGYLS DVASPPLMTS
PFQQSPSMPL NHLPGMPDAH MSINHLNMAG KQDMAMGSSS RMAFDSVPPR LSHLPVSSPS
TVMSSAPMNF TVGGAASLNG QCDWLTRLQN GMVQNQYNPM RSNIQPGAHQ QTQALQHAMM
TSLHNGMPTT TLSQMMSYQP MPNTRLASQP HLMQAPQLQQ IQQQQQNLQQ QLQQQNLQQQ
QHHNTSSNTN AHISQNFLSN ELNQSDMQQV SSTTMTVHTI LPQETQILST SLPSSLTQPM
TTTQFLTPPS QHSYSSPLDN TPNHQLQVPD HPFLTPSPES PDQWSSSSPH SNISDWSEGI
SSPPTSMQSQ IGHIPEAFK
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