ID A0A4D9EEZ3_9SAUR Unreviewed; 134 AA.
AC A0A4D9EEZ3;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 28-JUN-2023, entry version 16.
DE SubName: Full=Islet amyloid polypeptide {ECO:0000313|EMBL:TFK06082.1};
GN ORFNames=DR999_PMT11264 {ECO:0000313|EMBL:TFK06082.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK06082.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK06082.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK06082.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK06082.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK06082.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK06082.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK06082.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK06082.1}.
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DR EMBL; QXTE01000103; TFK06082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9EEZ3; -.
DR STRING; 55544.A0A4D9EEZ3; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.2190; -; 1.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR InterPro; IPR000443; IAPP.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR PANTHER; PTHR10505:SF4; ISLET AMYLOID POLYPEPTIDE; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00818; ISLETAMYLOID.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..134
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020030040"
FT DOMAIN 77..119
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT DISULFID 80..85
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 134 AA; 14789 MW; 8A1AB37B8145DC05 CRC64;
MCNLKLPVVF IVLSVALSYL EATPMERLFS VADDLSDGSS NRQGWLLPVL SRNTPWGLNG
ALPQPAAAKP KSHRLEKRKC NTATCVTQRL ADYLVRSSNN IGAIYSPTDV GSNTYGKRDR
VGLLNREPLN YLQL
//
