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Database: UniProt
Entry: A0A4D9EHP3_9SAUR
LinkDB: A0A4D9EHP3_9SAUR
Original site: A0A4D9EHP3_9SAUR 
ID   A0A4D9EHP3_9SAUR        Unreviewed;       383 AA.
AC   A0A4D9EHP3;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00019474};
DE            EC=5.3.99.3 {ECO:0000256|ARBA:ARBA00012203};
DE   AltName: Full=Microsomal prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00031041};
GN   ORFNames=DR999_PMT08707 {ECO:0000313|EMBL:TFK08295.1};
OS   Platysternon megacephalum (big-headed turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Platysternidae; Platysternon.
OX   NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK08295.1, ECO:0000313|Proteomes:UP000297703};
RN   [1] {ECO:0000313|EMBL:TFK08295.1, ECO:0000313|Proteomes:UP000297703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08295.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:TFK08295.1};
RA   Gong S.;
RT   "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:TFK08295.1, ECO:0000313|Proteomes:UP000297703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08295.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:TFK08295.1};
RA   Gong S.;
RT   "The genome sequence of big-headed turtle.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-
CC         heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644,
CC         ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274;
CC         Evidence={ECO:0000256|ARBA:ARBA00023930};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645;
CC         Evidence={ECO:0000256|ARBA:ARBA00023930};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893,
CC         ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00023931};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894;
CC         Evidence={ECO:0000256|ARBA:ARBA00023931};
CC   -!- PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004702}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the GST superfamily.
CC       {ECO:0000256|ARBA:ARBA00007409}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TFK08295.1}.
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DR   EMBL; QXTE01000070; TFK08295.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4D9EHP3; -.
DR   STRING; 55544.A0A4D9EHP3; -.
DR   UniPathway; UPA00662; -.
DR   Proteomes; UP000297703; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050220; F:prostaglandin-E synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03197; GST_C_mPGES2; 1.
DR   CDD; cd03040; GST_N_mPGES2; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 6.20.200.30; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR011767; GLR_AS.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR034334; PGES2.
DR   InterPro; IPR034335; PGES2_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12782; MICROSOMAL PROSTAGLANDIN E SYNTHASE-2; 1.
DR   PANTHER; PTHR12782:SF5; PROSTAGLANDIN E SYNTHASE 2; 1.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SFLD; SFLDG01182; Prostaglandin_E_synthase_like; 1.
DR   SFLD; SFLDG01203; Prostaglandin_E_synthase_like1; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Prostaglandin biosynthesis {ECO:0000256|ARBA:ARBA00022585};
KW   Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        57..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          98..182
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          261..383
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   383 AA;  43530 MW;  A3C5852C6BAC5BEA CRC64;
     MAAACSGWRC LGQLPWRLRA AGQAAGVGLL RAQSRGYCIP FGTGRYARAR ALKGSRMLVG
     AAFALGGTFG LFQTLQYPLK DQEHLAEQQA AKLPAGSLQL TLYQYKTCPF CSKVRTFLDY
     HGVPYEIVEV NPVMRKEIKF SSYRKVPILL ANAGNALQLN DSSVIISAIK TYLVSRKKNL
     EEIVSFYPPM KTVNERGKEV TEYGNKYWLM LDEMEIQHVY PIKEARVEEM KWRKWADDWL
     VHLISPNVYR TPREALASFN YIVHEGKFGT VEGFLAKYVG AVAMFFIGKR LKSRHHLQDN
     VREDLYKAAN DWVKAVGANR PFMGGSQPNL ADLAVYGVLR VMEGLEAYDD MMTHTKIQPW
     YHRMEKAIGE AEVTNWQLLQ PPY
//
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