ID A0A4D9EIG7_9SAUR Unreviewed; 6337 AA.
AC A0A4D9EIG7;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Antigen KI-67 {ECO:0000313|EMBL:TFK08675.1};
GN ORFNames=DR999_PMT08431 {ECO:0000313|EMBL:TFK08675.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK08675.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK08675.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08675.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK08675.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK08675.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK08675.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK08675.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK08675.1}.
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DR EMBL; QXTE01000066; TFK08675.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9EIG7; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR CDD; cd19941; TIL; 8.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF371; MUCIN-5B; 1.
DR Pfam; PF08742; C8; 8.
DR Pfam; PF13330; Mucin2_WxxW; 5.
DR Pfam; PF01826; TIL; 3.
DR Pfam; PF00094; VWD; 8.
DR SMART; SM00832; C8; 8.
DR SMART; SM00041; CT; 1.
DR SMART; SM00214; VWC; 10.
DR SMART; SM00215; VWC_out; 5.
DR SMART; SM00216; VWD; 8.
DR SUPFAM; SSF57567; Serine protease inhibitors; 8.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
DR PROSITE; PS51233; VWFD; 8.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..6337
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020033487"
FT DOMAIN 81..251
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 435..610
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 901..1072
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2582..2766
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2913..2984
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3022..3089
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3160..3262
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DOMAIN 3259..3429
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3620..3795
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 4089..4258
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 5897..6080
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 6225..6296
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1446..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1780..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2020..2045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2072..2105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2154..2179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4683..5657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5809..5834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4683..4713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4725..4792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4804..4871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4883..4950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4962..5094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5106..5173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5185..5252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5264..5331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5343..5410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5422..5489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5501..5568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5580..5657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5809..5827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3184..3233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 3195..3249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 6337 AA; 678596 MW; 8553387E3BAD272E CRC64;
MGIGWGVRIP LWIPILVITF MQNKVKAQYE DQQANYDDYN YVQQGQDYFS VPVTKPQEVT
IIQPLRTTLP VKPGNPAHNG RVCSTWGNFH FKTFDGDIFH FPGLCNYVFA SHCKSAYEDF
NIQIRRTVLE SSPVISHISL KLDGSVIELT SDSIVVNGNP IQLPFSQSGI LIERSSGYLK
ITAKMGLVFM WNQLDGLLVE LDKKYANQTC GLCGDFNGIP IYNEFTSNNI KLTDVQFGNM
QKMDGPTEQC EDPTSSSLSN CSNEFSAICQ RVLTGEAFVS CNALVDIQDY IDSCVQDLCR
CDESMRDFCI CNTFAEYSRQ CAHAGGQPLN WRTKELCNKT CPYNMQHEEC GSPCANTCTN
PERSALCEDH CTDGCVCPPG TVSDDINSSG CVPLSECHCT YKGETYSPGA SFASQCTSCT
CTGGQWSCVS LSCPGTCSIE GGSHISTFDE KRYSFFGDCS YILTKLCDSD AFTVLGEVRK
CGLTDTETCL KGVAISIGGG QTIAVIKPSG SVFVNTIYTQ LPISAANVTI FRPSSFFINV
QTNFGLQVQI QLVPIMQLFV NLDPSHKGQT CGLCGNFNNI QADDFKVTSG VVEGTAAAFA
NSWKIQADCP NVKNIFENPC TLSIENEKYA QHWCGLLTDT QGPFAECHST VNPDVYHTNC
MFDTCNCEKS EDCMCAALST YVRACAAKGV LLNGWRTNVC TITSCPKSLT YSYIVNSCQP
TCRSLSEPDV TCNIKFTPVD GCTCANGTYM DENGKCVPAT SCPCYYKGSV LPSGEVVHDN
GVICSCTHGK LDCVRVKPEP VCAAPMVYFD CSNVTAGTIG SECQKSCQTL DMGCYSTQCI
SGCMCPNDLV SDGKGGCVAA GECPCVHNEA SYNPGETIKV NCNTCTCKNR MWQCTNEPCL
ATCSVYGDGH YITFDGKRFS FSGDCEYTLV QDYCGKNSTS LGTFRVITEN IPCGTTGTTC
SKAIKVFLGN YELVLSDGKF EVIEKVRGGE VPYKVRYMGI YMVIDTDNGL ILMWDKKTSI
FIKLSPDFKG QVCGLCGNYD GNGINDFTTR SQSVVGDVLE FGNSWKVSPT CPDAKSNKDP
CTANPYRNSW AQKQCSIINS KVFAACHSQV EPNEYYEACV TDACACDTGG DCECFCTAVA
SYAQACNEAG ICVAWRTPSI CPLFCDYYNP QGECEWHYKP CGSPCMKTCR NLSGKCLHEL
QGLEGCYPKC PENKPYFDED DMECVDHCGC YDTKGKYYKP GTPIRSEENC QSCECTMNGI
KCEYDEDECH CTYDGKQYEY EDVIYDTTDG IGGCIIATCG HNGTIDRKVY ACSTPLTTTP
FSFSSSTPIS TTTVTPTTSV CVREVCQWSQ WYDVSYPGSG INDGDFDTFD NLRAKGYKVC
KAPKAVECRS EKFPDTPLNE LEQKVECSTT MGLICYNKDQ HQMICDNFQI KILCCSFVPC
EYTTPATTPP AETTTPITKT TTPETTVTSI SSTTTALPTT TEPKTTTLST SSMTSKTPST
TPVTETTSVS TSTLRTTAPS TTIPETTASP STETVYTTGE ITSITPCKPK CKWSEWHDVH
LPSLDNKGDS ETYDDIRAAG KVICSKPENI ECRAEKFPEK SIDNIGQIVQ CNVSFGLVCR
NEDQEEELQM CYNYQIKVFC CDDFSHCPST STTTETTTTA GTTIVSTETS TQTPTTTETT
TSTVRTTPST TTTTETTTKE VKTTTLLTTT PIETTTIITT PFTTTTTETT TTPGTPIVST
ETSTLTPTTT ETTSTIGTTH SSITSIETTT VTTTPFTATT TQTTTTTGTT TMTTPQTTTT
IPTTIPITST PIPDTFTTTT TSPTITQTTT TEFTTIVSTT NTPATTETTT AATTTPFSTT
KPTSSITVTT TPAITTISET TTAVTTVPLT PDDCIKELCE WSQWYDISYP GSAINDGDFD
TFKNIRAKGY KVCKAPKAVE CRAERFPNTP LNELEQNVIC SKTEGLICYN KDQLPPICYN
YQIKIECCRN VIVSCLTTTP ATTTTVTTIP ATTQIVTTTP GTTPIVTTTP PIPTTTPTIT
PIGTTTTATT PIVTTISPTT TTVTTIPTTT EIVTTTPGTT PIVTTTPPIP TTTPTNTPIG
TTTTATTPIL TTTTATTRVT TTPATTPIET TTSTTIPIGP MTTATTMTVT TTPATTTVTT
TPTTTSIETT TPPTTPIVTT TPATTTIVTT STTATTKKII TQIKTTTKAQ TAPIHVETTK
EMHSTTKETT LLSKTTPERT PVTTSTISTT LPTTTSLETT NSETTRSGTT TGTTTLPTTE
IPTTLPTSTT TGTTTSSTTV CEPTCTWSKW FNVDFPSSGP KEGDIETYKN IRAAGEIFCG
KPASIQCRAE SYPEISIDEV GQVVQCDVNL GLVCKNEDQI GKYKMCFNYE VRVFCCEENV
NCPVTTSILS TMPTRVTTPT ISSTQTGTTE VTMTTTHCFC QIEDAVYASG EMIYNEIDKD
GCNFYAICSK TCSVERFKGP CKSTTPATIT TPTTSTSIPT TTPTTTVSST TKIECPDAKP
PRKTGETWKI SNCTTATCEG NNKVVIQKVK CPHVKRITCA NGYPPVKVFS EDGCCYHYEC
ECVCSGWGDP HYITFDGTYY TFLDNCTYTL VKQITPKYDN FRVDIDNYFC DAEDGLSCPQ
SIIVYYKYTV VVLTRELYNG VMANKIIFNK TVVNPGFQKD GISIYMLGIN MVVEIPEIGA
TITFSGLIFS VKLPFSKFGN NTEGQCGTCT NIKTDDCRLP SGKIIPSCTQ MAPHWKVDDG
KKQYCVGTPT PPPGPSTPTP APSCPPSALC KIILSEVFEE CHKVIPPQDF YKGCVFDACH
MTNTSMQCSG LEIYATLCAT RDVCVDWRGE TKGKCPYNCP VGKVYKPCGP LNPATCDPRA
VQHNSTGLTE GCFCPEGKFL FNANSGVCIP DCDICIGTDG LPKLPGDQWK SNCQDCVCDK
YTLTVQCTKR PCKPLPPVSC DDPGFAPVQS LTQEDPCCVQ TECRCDTSKC PESVASCQPG
YELIPEVLIG NCCTIFTCKL IPGCVTNGTF YMPGAVIPKG TCEKCTCSAK VQPDSQRNIV
DCQPIPCDTE CPVGYEYKMK TGQCCGDCVP KACVLKMEDN TVHVLQAGKV WHEPGDNCTF
YKCEQIEDQF IPVTVRKVCP PMYPENCDPA DVMLSQDGCC KTCPLPRKTC GLHNTTTVIS
HNECSSSVPV ELTYCEGNCD TSSMYSLEAN VMQHKCKCCQ EVKTSKRQVT LNCPDGSTTD
YSYIHVEQCD SFNPAHNGRV CSTWGNFHFK TFDGDIFYFP GLCNYIFASH CNAAYEDFNI
QIRRAVVKNV PTINHVTMKL DGVVFEMAKN FVVVNGNRVQ LPYSQSGIMA ERSSMYTKVT
AKMGLVFMWN EDDSILLELS DKYANYTCGL CGDFNGIPTY NEFFSNNAKL TATQFGNMQK
MDGPTEVCED PTSSSLNNCT DNFDDICHKV LTGPAFSECN ALVEVSEYIK SCEQDLCRCD
QSKNAFCICN TFGEYSRQCA HAGGQPLNWR TPQLCPKKCP FNMQYQECGS PCTDTCTNPE
RSQVCEDHCM DGCFCPPGNF FLHLGTVLDD INNAGCIPLW ECSCTYNGNS YAPGTSFHAH
CHSCTCNGGQ WICKDIPCLG SCTVEGGSHI STYDEKRYNV HGDCTYVLSK LCENDTFAVL
GELRRCGLTD TETCLKTIAL SVNGGQTMIE IKHGGGVFVN WIYTQLPFSA ANVTIFRPSS
FFIMVETNFG LQLEIQLVPI MQAFVRLDPS FKEQTCGLCG NFNNIETDDF KAISGVVEGT
AAAFANTWKT QALCHDIKNN FENPCALSVE NEKYAKHWCG LLMDSTGRFA NCHFTVNPAV
YHTNCLFDTC NCEKSEDCMC AALSSYVRAC AAKGVKLEGW RTDVCSKYTT SCPKSLSYSY
NISSCQPTCR SLSEPDVTCN IRFIPVDGCT CEKGTYMDEY GKCVSASECP CYYKGSPILS
REAVHEDGLV CTCAQGKLSC IGAVNQIPVC APPMVYFDCR NVTAGTTGAE CQKSCQTLDM
QCYSTQCMSG CMCPSGLVSD GKGSCIAEEE CPCIHNEATY KPGEEIKVDC NTCVCKNRMW
KCTSEQCLGT CAIYGDGHYI TFDDKRFNFN GDCEYTLVQD HCGKNSTVNG TFRVVTENIP
CGSTGTTCSK SIKVFLAGYE LILSEEHLEV VERENGRQMP YQVRYMGMYL VIETNNGLIL
MWDKKTSIFI KLSPDFKVCG LCGNYDGNGI NDFTTRSQSV VGDVLEFGNS WKVSPTCPDA
NSTKDPCATN PYRKSWSQRQ CSIINSEVFA ACHSQVEPTK YYEACVTDAC ACDSGGDCEC
FCTAVAAYAQ ACSEFGVCVA WRTPSICPMF CDYYNPEGGC EWHYKPCGAP CMKTCRNPSG
RCLHKLPGLE GCYPNCPANK PYFNEDEMTC VDNCGCYDAE GNYHKPGVSF YSRDNCQSCH
STSCFTACYC YYEEHKYNYK DVIYNTTDGI GGCLSATCDI NGTITRKFFE CSGITTTTPF
TFSTVLPTRT TTTAPVTTVC VHNVCQWSEW YDSSNPTKDS SNGDFETFEN LRANGHRVCK
TPSEVECRAK NNPGTTQTYL KQKLTCSKDI GLICENMDQI PPICYNYEIR ILCCTYVPCE
PSTSTPSVTT SGIPKVTATS LESETVSNPI ASISTEGPIP FPLPNTSSVT ITLIPQVSTT
VSVTSTASPP TPGTSTSSPG TASLQTGTIP PVTGTRPQPS PGSTLPPLGR TTTEGTTLLS
TQPTSEGSTT TLIPPVFTTV SVTSTASPPT PGTATGSAGT ATLQTGTIPP VTGTRPQPSP
GSTLPPLGRT TTEGTTLLST QPTSEGSTTT LIPPVSTTVS VTSTASPPTP GTATGSAGTA
TLQTGTIPPL TGTRPQPSPG STLPPLGRTT TEGTTLLSTQ PTSEGSTTTL IPPVSTTVSV
TSTASPPTPG TATGSAGTAT LQTGTIPPVT GTRPQPSPGS TLPPLGRTTT EGTTLLSTQP
TSEGSTTTLI PPVSTTVSVS STTSPPTPGT ATGSAGTRPQ PSPGSTLPPL GRTTTEGTTL
LSTQPTSEES TTMLIPPVST TVSVTSTASP PTPGTATGSA GTATLQTGTI PPLTGTRPQP
SPGSTLPPLG RTTTEGTTLL STQPTSEEST TMLIPPVSTT VSVTSTASPP TPGTATGSAG
TATLQTGTIP PLTGTRPQPS PGSTLPPLGR TTTEGTTLLS TQPTSEGSTT TLIPPVSTTV
SVTSTASPPT PGTATGSAGT ATLQTGTIPP LTGTRPQPSP GSTLPPLGRT TTEGTTLLST
QPTSEGSTTT LIPPVSTTVS VTSTASPPTP GTATGSAGTA TLQTGTIPPL TGTRPQPSPG
STLPPLGRTT TEGTTLLSTQ PTSEGSTTTL IPPVSTTVSV TSTASPPTPG TATGSAGTAT
LQTGTIPPVT GTRPQPSPGS TLPPLGRTTT EGTTLLSTQP TSEGSTTTLI PPVSTTISVT
STASPPTSGT STGSAGTASL QTGTIPPVTG TRPQPSPGST LPPLGRTTTE GTTLLSTQPT
SEESTTMLIP PVSTTVSVTS TASPPTPGTA TGSAGTATLQ TGTIPPLTGT RPQPSPGSTL
PPLGRTTTEG TTLLSTQPTS EGSTTTLIPP VSTTVSVAST ASLPTPGTST SSGGTASLQT
GTIPHVTGTR GGMTTDSASM VKGSTITGST MLFSTSPAQP TSQGSTSTLL SPVSTTFAVS
PTLSIRTPAT STISRLTSSV SATEGPSTAY TAREKSTSFT SSRVTPCLCH VSGDFFSPGD
VIYNRTDSTG CSFYALCSKR CEIERFQRPC PTTTPVSLIP SSTIPSLSTP TAISSSVPAT
PATSKPTPVS GCPDADPPRK MNESWMLNNC TTATCEGDNR IVLLLPPAVE TITCASGLPP
IKVYDEDGCN YHYECDCVCS GWNNFHYLTF DGTHYTFYDN CTYVLMKQIV PKYNFSILVD
NDFCDVADGL SCPRSIIVNY NSMEIVLSSQ IHQGEKNNKI LVNNEPISGG FSRDGISVAN
GGTYMVVEIP DIKSYISFNG LTFTVKMPFS MFGHNTEGQC GTCSNDKVDE CRMPNGEVIS
SCSEMAAAWQ VQDENKPNCE GPPVPPATPT TPPVPCNSTS HLCELILSDL FAECHKILTP
SIFYESCVAD SCHITNESIP CFSLETYASL CSAKGVCADW RSKTQGQCPY NCPNGKVYDA
CGPLNPVTCN SGTVNHTSEH VAEGCFCPKD KILFNSYTDV CVSECACVGP DGMPKLPGAI
WKSNCQECVC DPFSVTVQCK SLTCQTPETR MCEKEGFIPV PVLTPEDPCC PEIECRCNTS
ACSQAKKTCE PGYQLATILS EGDCCVNYTC GKLLCFF
//
