ID A0A4D9EJN8_9SAUR Unreviewed; 575 AA.
AC A0A4D9EJN8;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000256|ARBA:ARBA00039240};
DE AltName: Full=Glucose transporter type 10 {ECO:0000256|ARBA:ARBA00042909};
GN ORFNames=DR999_PMT09422 {ECO:0000313|EMBL:TFK07768.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK07768.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK07768.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07768.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07768.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK07768.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07768.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07768.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Facilitative glucose transporter required for the development
CC of the cardiovascular system. {ECO:0000256|ARBA:ARBA00037777}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000256|ARBA:ARBA00000618};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004127}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000256|ARBA:ARBA00007004}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK07768.1}.
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DR EMBL; QXTE01000079; TFK07768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9EJN8; -.
DR STRING; 55544.A0A4D9EJN8; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17436; MFS_GLUT10_Class3; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR48023; D-XYLOSE-PROTON SYMPORTER-LIKE 2; 1.
DR PANTHER; PTHR48023:SF7; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 10; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..534
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 405..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 63195 MW; 63D3976028B1F375 CRC64;
MGRALLVLLL PATVSLLGGL MFGYELGIIS GALLQLQMDF HLSCFEQEIL VSSLLIGALL
ASLVGGILID RHGRRRAILV SNLILLCGSL ILTLAGSLIW LVFGRMTVGF AISVSSMACC
IYVSEMVAAH QRGLLVSLYE AGITVGILLS YALNYIFSDM TEGWRYMFGL ALAPTVIQFL
SILLLPTKPF VLNLWDCDSQ KGLIQLQNNE DGEEAKPEPC KEKHYSFLDL FRSRDNMKSR
TLVGLGLVLF QQFTGQPNVL CYASKIFRSV GFQNDSSAVL ASVGLGVMKV IATLVAMFFA
DKAGRRVLLI AGCVVMSVSV TAIGLTSWTV PLDKARDCKT ATEPNASYTI AQHPMQPVSS
QPAVLYIPWT SAAGESQLSS SFALTRPEGL TKDFASTRNR EIITESSRTQ KMDLPNQSNE
ETVQNTSSPF SDTPNKEHMV LNWITLLSMM AFVSAFSIGF GPMTWLVLSE IYPAGIRGRA
FSFCNSFNWA ANLLISLSFL DLIDAIGLSW MFLLYGVVGV AAVIFIYLFV PETKGQSLEE
IDQQFSRKRI TSEEGMLKPM NWPKLEKVTQ IRPPQ
//
