ID A0A4D9ELK5_9SAUR Unreviewed; 1028 AA.
AC A0A4D9ELK5;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Putative G-protein coupled receptor 160 {ECO:0000313|EMBL:TFK11707.1};
GN ORFNames=DR999_PMT05106 {ECO:0000313|EMBL:TFK11707.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK11707.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK11707.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK11707.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK11707.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK11707.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK11707.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK11707.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK11707.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QXTE01000029; TFK11707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9ELK5; -.
DR STRING; 55544.A0A4D9ELK5; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:TFK11707.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..200
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 237..739
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 748..1024
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 111216 MW; D99A64126B07E413 CRC64;
MEGKQPLSGG AEETSRLPAR VGDVPAADAE PEAGLSPAAA AGDALCRPLG PSQSRFQVDL
VAEGSGRAAA DEPQKPGGQG GAAVKGSEEA KGRFRVNFVD PSAGDESPAE HGGGLEGGGV
SFQNGGDTVL SEGSLHSGGG GGHHHYYYDT HTNTYYLRTF GHNTMDAVPR IDHYRHTAAE
LGEKLIRPSL AELHDELDKE PFEDGYANGE EGTPPGEADA TYAADSKGIV KFGWIKGVLV
RCMLNIWGVM LFIRLSWIVG QAGIALSVLI IAMATVVTTI TGLSTSAIAT NGFVRGGGAY
YLISRSLGPE FGGAIGLIFA FANAVAVAMY VVGFAETVVE LLEQNGALML DDTNDIRIIG
AITVLVLLGI SVAGMEWEAK AQIVLLVILL LAIGDFIIGT FIPLDSKKVK GFFGYKAEIF
TENFGPDFRE DETFFSVFAI FFPAATGILA GANISGDLAD PQSAIPKGTL LAILITTLVY
IGLAVSVGSC VVRDATGNIN STIITELTNC TTAACKLNFD FSSCPKTPCS NGLLNDFQIM
STVSGFAPLI SAGIFSATLS SALASLVSAP KIFQALCKDN IYPGLLMFAK GYGKNNEPLR
GYILTFLIAL GFILIAKLNV IAPIISNFFL ASYALINFSV FHASLAKSPG WRPAFKYYNM
WVSLIGAILC CIVMFVINWW AALLTYVIVL GLYIYVTYKK PDVNWGSSTQ ALTYLSALQH
TVRLAGVEDH VKNFRPQCLV MTGAPNSRPA LVDLVHAFTK NVGLMICGHI YMGPRRQAMK
ELSTDLARYQ RWLIKNKMKA FYAPVHAEDL RDGGQYLMQA AGLGRMRPNT LVVGFKKDWK
QADTRDVETY INLFHDAFDI QYGVVVIRLK EGLDISHLQG QEELLSSQEK SPSSKDVVVN
VDYSKKTETD TSKAFSPPSS EKTPGLHKEE EEDGKTPTQP LLKKDSKGPQ APLNLADQRL
LDASSQFQKK QGKNTIDVWW LFDDGGLTLL IPYLLTTKKK WKDCKIRVFI GGKINRIDHD
RRAERKLI
//
