ID   A0A4D9ENQ7_9SAUR        Unreviewed;      1038 AA.
AC   A0A4D9ENQ7;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN   ORFNames=DR999_PMT04775 {ECO:0000313|EMBL:TFK11956.1};
OS   Platysternon megacephalum (big-headed turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Platysternidae; Platysternon.
OX   NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK11956.1, ECO:0000313|Proteomes:UP000297703};
RN   [1] {ECO:0000313|EMBL:TFK11956.1, ECO:0000313|Proteomes:UP000297703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO16091913 {ECO:0000313|EMBL:TFK11956.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:TFK11956.1};
RA   Gong S.;
RT   "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:TFK11956.1, ECO:0000313|Proteomes:UP000297703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO16091913 {ECO:0000313|EMBL:TFK11956.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:TFK11956.1};
RA   Gong S.;
RT   "The genome sequence of big-headed turtle.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TFK11956.1}.
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DR   EMBL; QXTE01000026; TFK11956.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4D9ENQ7; -.
DR   STRING; 55544.A0A4D9ENQ7; -.
DR   Proteomes; UP000297703; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000297703}.
FT   DOMAIN          506..754
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
FT   COILED          514..541
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1038 AA;  117916 MW;  86A8453E2AA8427E CRC64;
     MWGRYLAARR LLSLSRKFYF RTSNQKSWRW KSGSANERAL QYKIGEQIHG FTVNQVTAVP
     ELFLTAVKLS HENTGAKYLH VAREDSNNLF SVQFRTTPLD STGVPHILEH TVLCGSQKYP
     CRDPFFKMLN RSLSTFMNAF TASDYTLYPF STQNPKDFQN LLSVYLDAAF FPCLRQLDFW
     QEGWRLEHEN PTDPQTPLVF KGIVFNEMKG AFTDNERLFS QHLQNKLLPD HTYAVISGGD
     PLSIPDLTWE QLKQFHATHY HPSNARFFTY GNFPLEQYLK QIHEEALTKF HRIEPNTAIP
     VQQLWDKPRE HHVKCGSDSF AADPTKQTTI SVSFLLTDIT DTFETFTLNL LSSLLVGGPN
     SPFYKALLEA NLGTDFSPDV GFNGCTREAY FSVGLQGIAE KDIETVKQIT ARTIDEVIEK
     GFEEERIEAL LHKIEIQMKH QSTSFGLALT SYIASCWNHE GDPVELLKIA DKVTEFRQHL
     KENPTFLQEK VKQYFKDNPH RLTLSMSPDE SYYEKQAKLE AEKLKQKVNA LSEEEKKQMY
     EKGLELIALQ SKPQDTSCLP ALKVSDIEPT IPFTELEMAF AADEIPVQYC AQPTNGMVYF
     RAVSSLNTLP EDLKPYVPLF CSVITKMGCG ALGYREQAQQ MELKTGGMSV SPHIIPDDSH
     LDAYEQGVLF SSLCLDRNLP DMMHLWSEIF NNPHFEEEEH FRVLVKMTAQ ELSNGIPDSG
     HLYASVRASK TLTPAGELQE MFNGMDQVKL IKRIAEMSDI KPVLRKLPRI KKYLLNSDNM
     RCSVNATPQQ MSQASKEVEN FLKGIARSKK ERKPVRPHVI EKSPEPVPFG RERLNCSQIT
     RKLITEPTFK PCQMKTHFLL PFPVNYVGEC IRTVPYTAPD YASLRILARL MTAKFLHREI
     REKGGAYGGG ATLSHSGIFT FYSYRDPNST STFSTFEKAA EWAQSGEFAQ QDIDEAKLAV
     FAAVDAPIAP SDKGMNHFLN GISDEMKQRH REQLFAVSSD HLIDVANKYL AGGKSTRGLA
     VLGPENSHIA KDPSWVQR
//