ID A0A4D9EPS4_9SAUR Unreviewed; 1033 AA.
AC A0A4D9EPS4;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Integrin alpha-9 {ECO:0000313|EMBL:TFK07924.1};
GN ORFNames=DR999_PMT09235 {ECO:0000313|EMBL:TFK07924.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK07924.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK07924.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07924.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07924.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK07924.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK07924.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK07924.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK07924.1}.
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DR EMBL; QXTE01000076; TFK07924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9EPS4; -.
DR STRING; 55544.A0A4D9EPS4; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF69; INTEGRIN ALPHA-9; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 28..1033
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5019882382"
FT TRANSMEM 976..1000
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 29..94
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 288..347
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 349..406
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 409..472
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 457..616
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 618..762
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 770..966
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1033 AA; 115328 MW; 7CE278C0B9F60725 CRC64;
MPGPQGKVKR SWFKVLVGLI AVALAYSYNV DLDHPVVYQG PNGSFFGYSV LEHYYDNTRW
VLVGAPKADS KYSASVKSPG AVFKCRVHTN PERRCTELDM GRGNTQGTLC GKTCKEDRDD
EWMGVSLARQ PKADGSVLAC AHRWKNIYYE TEYVLPHGFC NIIPPNLHSN GRKLLPCYEE
YKKKYGEEHG SCQAGIAGFF TEELVIMGAP GSFYWTGTVK VLNLTDNTYF KLNDDAVIAR
RYTYLGYAVT AGHFSQPTTT DVVGGAPQDG GIGKVYIFRT DRQSGSLIKI FQASGKKMGS
YFGSSLCAVD LNLDGLSDLL VGAPMFSEIR DEGQVTVYIN RGNGVLEEQL VLNGDNAYNA
HFGESMASLG DIDDDGYSDV AIGSPKEDDY IGAVYIYHGD AGGIVPQYSM KLSGQTINPT
LRMFGQSISG GVDMDGNGYP DVTIGAFMSD NVVLLRSRPV ITMDISIFLP ASINITAPQC
HDGLQQVNCL NVTVCFRFNG KRVPGEIGLN YILTADVAKK EKSQQPRVYF VSSGETMGQV
LEQLQLSYMR EKCDHYLAYV KRRVKDVISP IVFEAAYSLG EHVMGKEEKE LPALKPILRW
KKGEKIAQRN QTVFERNCQS DDCAADLKLQ GKLLLSSVDE KTPYLALGAV KNISLNISIS
NIGDDAYDTN VFFNFSRELF FIKMWQKEEL GIACELLESD FLKCSVGFPF MRSKSKYEFS
VIFDTSHLSG EEEFLTFLVM AQSGNLEHSE SLHDNTLTLS VPLMHEVDSS ITGTVSPTSF
FYGGSVERSN FVQLENYECL FQPLNFTLQV YNTGPSTLPE SFVEILFPNR LSASGAETFH
IQQMMVAQEK GNCSFQKNPN PCVIPQENDN IFHTIFAFFT KSGRKVLDCE RPGRPCLIVR
CNLSSLAKAE SRNIDVYMLL NTEILKKDSS SVIQFVTRAK VRVDTTLRIV QVSNGNTEDP
KVVFEALHNL EARGYVVGWI IAISLLVGIL IFLLLAVLLW KMGFFRRRYK EIIEAEKNRK
ENENSWDWVQ KNQ
//
