ID A0A4D9F802_9SAUR Unreviewed; 3192 AA.
AC A0A4D9F802;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Protein FAM154A {ECO:0000313|EMBL:TFK15488.1};
GN ORFNames=DR999_PMT00782 {ECO:0000313|EMBL:TFK15488.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK15488.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK15488.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK15488.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK15488.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK15488.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK15488.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK15488.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK15488.1}.
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DR EMBL; QXTE01000004; TFK15488.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9F802; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..370
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 574..797
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1155..1259
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1944..2469
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2783..2960
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2965..3050
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3054..3167
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 1348..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..138
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3192 AA; 361141 MW; 58BFF2F18921B1CC CRC64;
MVFESLVVDV LNRFLGDYVV NLDSSQLSLG IWGGAVALKN LEIKENALSQ LDVPFKVKAG
HIGQLNLQIP WKYLYTQPVE AVLDGVYLLI VPTASIKYDA EKEDRQLLEA KQRELQRIED
AKQKIADQDK GKEEKQDTFV EKLVTQVIKN LQVKISNIHV RYEDDITNRD NPLSFGVSLQ
NLSLQTSDQN WNPCLHDEAT KLFYKLVRLD NLFAYWNVKS VMFYHGGYDE SLNNLKHGVA
CRNVIPEGYD FVFRPISAKA KLRMNPRSDF DFSSPKMDLD VNLQDIAIEF NKPQYFSIME
LLESIDMMTR NLPYRKYRPD VLLHNNAKMW WKYIIKGILE VNVQPKLNMW SWEHIRHHRK
QVKNYKEMYK MKITSKKPSE EIVKLLEEFE KTLDIFNITL ARQQAEVEVT KAGLKIYRPG
VKQDDENSGG WFSWIWGWSG EKNDENKQEI KGASFEELMT LEEKAKLYAA IGYSETAVDP
TLPKTYEAMK LSVKLLSMSI SIRENKEKPE LIKFAIIDLS TMLMQRPGAQ AIRFETKIST
FEVTGMSQEK FIPCLLSSRT IHSENNTSLL SIMFETNPLD EKADQKLRIE SQPLEIIYDA
RTVNSLVDFF RPPKDVHLEQ LTSATLMKLE EFREKTSTGL LYVIETQKVL DLKINLMASY
VLVPQNGFYE STSNLLLLDL GNLQMTSKSR SDVSELKVGK STIEDIMSRA YDSFDIQLSS
IQLLYCKHHE NWKEARKLKY SSQHILRPMD VKVEFSRAMV VTDARMPKFK IFGQLPLLSV
QISDQKLMGI LELIDSIPKP ESGPATMSAP KPTQIAVTPL LATPPVSKTV LPLLELHSLT
ESESEEEFYD APTSPVEEMP FFEASSGSLT RVNSVRRKRL QKQESLKNMT AFQLRFEISE
VLIQLCRLAD GTEKPVLQLE VVGLGTELKL RTFDMAANAF LREVCLLCPE YMDDKDKPVY
IITTLDNTED DLLTLEYVKA DINGPELKTA YKNVLQLLKV NFSSLDVHLH NEALLNAMNY
LNNLLPKQET KITEEVVQEK EEKKDVLKKL TSKKSKYEDV IDLHVCADLS CLRVFIREQK
RRISEIHIEG LDCQVIMRKA ATEVFAKLKN IIIIDSDEMA WYKKALYITG KEVFSFKMVS
YMDATDGAAY TNMNIVDSQV YLTVGCIQVV FVNKFVSTIL AFINNFQAAK EAITEATVQA
AEKAATGVKE LAQRSSRMAL DINIKAPVII VPQSADSTNV LVADFGLITV KNQFSVKTKA
QCSLPPVIDC MTVKLSELKL YRAHFERGSL QSEIQLLQPL NLEVIVERNL AAAWYSEVPD
IKILGRLKPM NLVLSQEDLT TILRTLNENL GDSSGAPPPL PEPKDTSSNG SDALSTSQHS
AGITMVTTAV VELRSPVKVK TTLKLDFLFD SLTLVLYSPN SKQVSALDQR DDRLKLAEFK
LVLISAAVKM LSDGSMNASV KLANCTLDDK RLTVQKTTSR MVEMKHGSEK KDMVDISYKQ
GRDGTVLDTI VQDIYLCASM EFLLTVADIF LKANAESAAA QRNIKQTLAV KEQASMQPVS
SMEMNIIVKN PEIVFVADLT RSDAPALVVT TQCEIFIKNS PQMYKMTAAV KDIQMKACPF
LAEKRKGNIT TVLQPCDFFF KMVQSGTNPQ MADLSIKSLT IKVSPIIINT VITITSALSP
TTETSEEEIS PIPPDLWDKK DTKNLKMWFL EKSNENENKT TAAELVLTGE TLNMRIESVI
VTLEAGVGHR TVPMLLAKSS FSGEVKNWST LINLHSQLEL EVHYYNEMFG VWEPLLEPLE
IEKSDEFKPW TLGIKMKKKA KEALESDAEE EHYKVPEYKT IINISSKDQL NITLSKCGLQ
MLSNLGMAFA EAASKTSDIF KKDQAPFVIM NSLGLPIIVS PSDSFKVLNV ESGAKTFHLK
DGESLNMEFL RTKSESDQFT AMTTLSSKMF YIQLSPHKHS TADKIPLTKV GRCLYRVRHE
ESGVERSIVC QIDTVEGSKI ITIRSPLQIR NHFSIPLSLF EDGTCLGTAS PINEFNIPLT
SYRSLLCLQP VTDENGIGGE YEMCEGIRFD EIMKNVGNLI QRKCQSVKST NHSLIINVVP
VKDTLTSSVC ADDRWDLPYV IHLWPSVLLR NLLPYPITYS LEGNVNKLDT LEDGCSTQIH
NAVLDQTKLE LQLLNYLDQN WKSEYHIRTN QQEIGFITFS CITEVDKTEL DIAVHVTYAT
GQMIIAIHSP YWMVNKTGRM LQYKADGIHR KHPPDYKKPL LFSFQPKNFF QNNKVQLMVT
DSELSDQFSL DTVGSHGSVK CKSHKKEYHV GVTIDNSSFN ITRIVTFTPF FMVANRSKYT
LEVAEEGKEK WIPITFQQCI PFWPENDSNK LLIRVENSNI PPKMICFNKQ ENCTLLYLDN
KLGGIIVDVN LTEHSTVITL SDYHDGAAPF LLINHTKEEM IEYGQSSLNV MEDCLMPNKA
VLYTWADPVG SRKLKWKCGK CSGEVTQKDD MMDSLILDHK KRVYLVSFFE GLQRIILFTE
DESVFKATYE SEKVELAEQE IVLSLQDVGI SLVNNYTKQE VSYIGITSSD VVWETKPKKK
SRWRPMSIKQ TEKLEREFKE YSELSPSENK IVELETNVMV CLTPNGGNMK IQQPNEIPVR
RNYLPALNVE YSTSAHQKSF RVQVYWIQIQ NQIPGAIFPF VFYPIKPPKS ITLDSAPKPF
IDVSIVMRTA GHSQISRIKY FKVLIQEMDL KLDLGFLYAL AELFTQAEVP KDQEVELFKK
DIESVQKELM SMSSTDTSQI SLYEYFHISP IKLHLSFSLS TGGEDSNKEE RQHELIPVQS
VNLLLKSIGA TLTDVQDVVF KLAFFELRYH FCTTQQLQSA VIRHYSKQAI KQMYVLILGL
DVLGNPFGFI RDLSEGVEAF FYEPYQGAIQ GPEEFVEGMA LGLKALVGGA VGGLAGAASR
ITSAMAKGVA AITMDEDYQQ KRREAMNKQP TGLREGITRG GKGLVSGFVS GITGIVTKPI
RGAQKEGAAG FFKGVGKGLV GAVARPTGGI IDMASSTFQG IKRATDSSDD VTSLRPPRFF
CEDGVIRPYR LRDGTGSQML QKIENGRFAK LRYITHAMVN NTDLLIITKS GLLFVTKGTF
GQLTCEWQYT YDEFTKEPFI VDGRRLRIEA KERVKSVFHA KEFGKIINFR TPEDAKWILS
KLEEVRESHP KL
//
