ID A0A4D9F851_9SAUR Unreviewed; 5174 AA.
AC A0A4D9F851;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 03-MAY-2023, entry version 13.
DE SubName: Full=Putative malate dehydrogenase 1B {ECO:0000313|EMBL:TFK13784.1};
GN ORFNames=DR999_PMT02802 {ECO:0000313|EMBL:TFK13784.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK13784.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK13784.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK13784.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK13784.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK13784.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK13784.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK13784.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK13784.1}.
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DR EMBL; QXTE01000014; TFK13784.1; -; Genomic_DNA.
DR STRING; 55544.A0A4D9F851; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1642..1715
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1642..1715
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 540..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1720..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2415..2460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2707..2760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2829..2963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3335..3377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2829..2887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2924..2946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3335..3356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3357..3376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5174 AA; 573555 MW; 5F8710B2F28F529B CRC64;
MAASGGGAET PGEPGWEVAV RPLLSASYSA FEMRELPQLL ASVIESESEI LHHDKQYEPF
YSSFVALSTH YITTVCGLIP RNQLQSVAAA CKVLIEFSLL RLENPDEACA VSQKHLILLI
KGLCTGCSRL DRTEIITFTA MMKSAKLPQT IKTLSDVEDQ KELASPVNPE LRQKEVQMNF
LNQLTSVFNP RVTASPSLVP DTQVEGESDN QTSTDQASAA KTKSIFIAQN VASLQELGGS
EKLLRVCLNL PYFLRYINRF QDAVSANSFF IMPATVADAT AVRNGFHSLV IDVTMALDTL
SLPVLEPLTP TRLQDVTVLA LSCLYAGVSV ATCMAILHVG STQQVRTGST SSKEDDYEND
AATIVQKCLE IYEMIGQAIS NSRRAGGEHY QNFQLLGAWC LLNSLFLILN LNPTALADKG
KEKDPLAALR VRDIIARTKE GVGSPKLGPG KGHQGFGVLS VVLANHAIKL LTSLFQDLQV
EALHKGWETD GPPAVLNVMA QSTSIQRIQR LIDSVPLTNL LLTLLSTSYR KACILQRQRK
GSVSSDASAS TDSNTYYEDD FSSTEEDSSQ DDDSEPILGQ WFEETISPSK EKVAPPPPPP
PPPLESSPRV KSPNKQTAGE NGNILASRKD PELFLSLASN ILNFITSSML NSRNNFIRNY
LSVSLSEQHM ATLASIIKEV DKDGLKGTSD EEFAAALYHF NHSLVTSDLQ SPTLQNTLLQ
QLGIAPFSEG PWPLYIHPQS LSVLSRLLLI WQHKASAQGD PDVPECLKVW ERFVGTLKQN
ALQGTLPNDT EDLNVEHLQL LLLIFHNFSE KGRRSILTLC IQTILELIVN MDSQLRSVPL
ILARLLLVFD YLLHQYSKVP VYLFEQVQYN LLTQPFGWVS GSQDSSRRIS VPLYHGFKEV
EENWTKHCSS DAVPQPRFYC ILSPEASEDD LNRLDNMVCE VLFSRTMKYD ELYAALTSLL
AAGSQFDTLR RKENKNVTAL EACALQYYFL ILWRILGILP PSKNYLNQLA MNTPEMSECD
ILHTLRWSSR LRISSYVSWI KDHLIKQGMK AEHAASLIEL ASTKCSSVKY DVEIAEEYFA
RQISSFCGID CTTILQLHEV PSLQSIYTLD AAISKIQVSL DEHFSKLAAE TDPHKSSEIT
KNLLPATLQL IDTYATFTRS YLLQSLSEEG STENKPSEEK LRGYAAVLAI GSSRCKSNTL
GPTLVQNLPS AVQALCESWN NIHTNEFPNI GSWRNAFAND TIPAESYISA VQAAHLGTLC
SQTLPLAASL KHTLLSLVRL TGDLIVWSDE LNPPQVIHTL LPLLLETSME SVAEISSNSL
ERILGPAESD EFLARVYEKL ITGCYNILAN HSDPNSGLDE SILEECLQHL EKQLESSQAR
KAMEEFFSES GELVQIMMAT ANENLSAKFC NRVLKFFTKL FQLTEKSPNP SLLRLCGSLA
QLACVEPVRL QAWLTRMTMS PPKDSDQLDV VQENRQLLQL LTTYIVRENS QVGEGVCTVL
LSTLIPMATE MLANGDGTGF PELMVVMATL ASAGQGAGHL QLHSAAVDWL GRCKKYLSQK
NVIEKMNANV MHGKHVTILE CTCHIVSYLA DVTNALSQTS GQGPSHLSVD GEERAIEVDS
DWVEELAVEE EDSQAEDSDE DSLCNKLCTF TITQKEFMNQ HWYHCHTCKM VDGVGVCTVC
AKVCHKDHEI SYAKYGSFFC DCGAKEDGSC LALVKRTPSS GISSTMKESA FQSEPRVPES
VIRHASSSPA DKSKVTINDG KGPDEEKPKK SSLCRNVEGC REELQSQANF SFAPLVLDML
SFLMDAIQIN FQQASAMGSS SRAQQALNEL HTLDKTVEMT DQLMVPTLGS QEGAFENVRM
NYSGDQGQTI RQLISAHVLR RVAMCVLSSP HGRRQHLAVS HEKGKITVLQ LSALLKQADS
SKRKLTLTRL ASAPVPFTVL SLTGNPCKED YLAVCGLKDC HVLTFSSSGS VSDHLVLHPQ
LATGNFIIKA VWLPGSQTEL AIVTADFVKI YDLSVDALSP TFYFLLPSSK IRDVTFLFNE
EGKNIIVIMS SAGYVYTQLM EETSSAQHGP FYVTNVLEVN HDDLKDSNGQ VAGGGVSVYY
SHVLQMLFFS YCQGKSFAAT ISRATLEVQR LFPINIKSSN GGSKTSPALC QWSEVMNHPG
LVCCVQQTTG IPLVVMVKPD TFLIQEIKTL PAKAKIQDMV AIRHTACNEQ QRTTMILLCE
DGSLRIYMAN VENTSYWLQP SLQPSSVISI MKPVRKRKAA AITTRTSSQV NFPIDFFEHN
QQLTDVEFGG NDLLQVYNAQ QIKHRLNSTG MYVANTKPGG FTIEVTNNNS TMVMTGMRIQ
IGTQAIERAP SYLEIFGRTM QLNMTRARWF DFPFTREEAL QADKKLTIFI GASVDPAGVT
MMDAVKIYGK TKEQFGWPDE PPEDFPSASV SNVCPPNLNQ GNGTGDLESA TPAAASGTVL
ESSETESLTI LDRLVVSSLE ALESCFAVGP VNEKEKSKAA AQELATILLS MPAPSSVQQQ
TKSLLASLHT SRSAYHNHKD QALLSKAIQY LSSSSKEGKD LDPEVFQRLV ITARSIAIMR
PNNLVHFTES KLPQMETEGG EEGQEAQKHT EGDGCSFITQ LVNHFWKLHA SKPKNAFLAP
ACLPGLTHVE ATVNALVDII HGYCTCELDC INTASKIYMQ MLLCPDPAVS FSCKQALIRV
LRPRNKRRHV TLPSSPRSNT PMGDKDDDDD DDAEDKMQSS GIANGEHIRQ ESQEQSEVDH
GDFEMVSESM VLETSENVNN GNPSPLEALL AGAEGFPPML DIPPDADDET MVELAIALSL
QQDQQGSSSS ALGLQSLGLS GQAPSSSSLD AGTLSDTTAS APASDDEGST AATDGSTLRT
SPADHGGSVG SESGGSAVDS VAGEHSVSGR SSAYGDTTAE GHPAGPGSVS SSTGAISTTT
GQQEGDGSEG EGEGEAEGDV HTSNRLHMVR LMLLERLLQT LPQLRNVGGV RAIPYMQVIL
MLTTDLDGED EKDKGALDNL LSQLIAELGM DKKDVSKKNE RSALNEVHLV VMRLLSVFMS
RTKSGSKSSI CESSSLISSA TAAALLSSGA VDYCLHVLKS LLEYWKSQQN DEEPVATSQL
LKPHTTSSPP DMGPFFLRQY VKGHAADVFE AYTQLLTEMV LRLPYQIKKI ADTNSRIPPP
IFDHSWFYFL SEYLMIQQTP FVRRQVRKLL LFICGSKEKY RQLRDLHTLD SHVRGIKKLL
EEQGIYLRAS VVTASSGSAL QYDTLISLME HLKACAEIAT QRTVNWQKFC IKDDSVLYFL
LQVSFLVDEG VSPVLLQLLS CALCGSKVLS VTSSSGSSST SSTSAPAGQP ATQSKSSTKK
SKKEEKEKER EGESSGSQED QLCTALVNQL NKFADKETLI QFLRCFLLES NSSSVRWQAH
CLALHIYRNS NKSQQELLLD LMWSIWPELP AYGRKAAQFV DLLGYFSLKT QQTEKKLKEY
SQKAVEILRT QNHILTNHPN SNIYNTLSGL VEFDGYYLES DPCLVCNNPE VPFCYIKLSS
IKVDTRYTTT QQVVKLIGSH TISKVTVKIG DLKRTKMVRT INLYYNNRTV QAIVELKNKP
ARWHKAKKVQ LTPGQTEVKI DLPLPIVASN LMIEFADFYE NYQASTETLQ CPRCSASVPA
NPGVCGNCGE NVYQCHKCRS INYDEKDPFL CNACGFCKYA RFDFMLYAKP CCAVDPIENE
EDRKKAVTNI NTLLDKADRV YHQLMGHRPQ LENLLCKVNE AAPEKPQEDS GSSGGISSSS
ASVNRYILQL AQEYCGDCKN SFDELSKIIQ KVFASRKELL EYDLQQREAA TKSSRTTVQP
TFTASQYRAL SVLGCGHTSS TKCYGCASAV TEHCITLLRA LATNSAIRHI LVSQGLIREL
FDYNLRRGAA TMREEVRQLM CLLTRDNPEA TQQMNDLIIG KVSAALKGHW ANPDLASSLQ
YEMLLLTDSI SKEDSCWELR LRCALSLFLM AVNIKTPVVV ENITLMCLRI LQKLIKPPAP
TSKKNKDIPV DALTTVKPYS NEIHAQAQLW LKRDPNASYE AWKKCLPARG TEANGKAPSK
TELRQLYLSE KYVWKWKQFM SRHGKRTCPL DLKLGHNNWL RQVLFTPATQ AARQAACTIV
EALATIPSRK QQVLDLLTSY LDELSIAGEC AAEYLALYQK LIKPAHWKVY LAARGVLPYV
GNLITKEIAR LLALEEATLS TDLQQGYALK SLTGLLSSFV EVESIKRHFK SRLVGTVLNG
YLCLRKLVVQ RTKLIDETQD MLLEMLEDMT TGTESETKAF MAVCIETAKR YSLDDYRTPV
FIFERLCSII YPEENEVTEF FVTLEKDPQQ EDFLQGRMPG NPYSSNEPGI GPLMRDIKNK
ICQDCDLVAL LEDDSGMELL VNNKIISLDL PVAEVYKKVW CPTNEGEPMR IIYRMRGLLG
DATEEFIESL DSTTDEEEDE EEVYKMAGVM AQCGGLECML NRLTGIKDFK QGRHLLTVLL
KLFSYCVKVK VNRQQLVKPE MNTLNVMLGT LNLALVAEQE SKDSGGAAVA EQVLSIMEII
LDESNAEPLS EDKGNLLLTG DKDQLVMLLD QINSTFVRSN PSVLQGLLRI IPYLSFGEME
KMQILVDRFK PYCNFDKYDE EHSGDDKVFL DCFCKIAAGI KNNSNGHQLK DLILQKGITQ
NALDYMKKHI PSAKNLDADI WKKFLSRPAL PFILRLLRGL ATQHPATQVL IGTDSITNLH
KLEQVSSDEG IGTLAENLLE ALREHPEVNK KIDAARKETR AEKKRMAMAM RQKALGTLGM
TTNEKGQVVT KTALLKQMEE LIEEPGLTCC ICREGYKFQP TKVLGIYTFT KRVALEEFEN
KPRKQQGYST VSHFNIVHYD CHLAAVRLAR GREEWESAAL QNANTKCNGL LPVWGPRVPE
SAFATCLARH NTYLQECTGQ REPTYQLNVH DIKLLFLRFA MEQSFSVDTG GGGRESNIHL
IPYIIHTVLY VLNTTRATSR EEKNLQSFME HPKEKWVESA FEVDGPHYYT VLALHILPPE
KWKAMRVEIL RRLLVIAHAR VVSPGGASRL TDKAVKEYSA YRSGLLFWAL VDLIYNMFKK
VPTSNTEGGW SYSLAEFIRH NDMPIHEAAD KALKTFQEEF MPVETFSEFL DVAGLLSEIN
DPDSFLKDLL NSIP
//
