ID A0A4D9FD08_9SAUR Unreviewed; 519 AA.
AC A0A4D9FD08;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Transmembrane protein 161B {ECO:0000313|EMBL:TFK15720.1};
GN ORFNames=DR999_PMT00594 {ECO:0000313|EMBL:TFK15720.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFK15720.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFK15720.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK15720.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK15720.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFK15720.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFK15720.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFK15720.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFK15720.1}.
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DR EMBL; QXTE01000003; TFK15720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9FD08; -.
DR STRING; 55544.A0A4D9FD08; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF3; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000313|EMBL:TFK15720.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transmembrane {ECO:0000313|EMBL:TFK15720.1}.
FT DOMAIN 50..238
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 270..365
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 451..499
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 519 AA; 60229 MW; 1C4EC5FFA61A740E CRC64;
MITLSEKLIL DCSKGIYKVA QILKSGFGSP NLCAVLQHAS KQKIILKSAF TLPDLTEQFL
PPDVAPPILI KIVEAIEKKG LECSTLYRTQ GSSSIAELRQ ILECDASSMD FEPIDVQILS
DALKRYLLDL PNSVIPASVY SEMISGAQEV QSSDEYAQLL KKLIRSPNIP HQYWLTLQYL
LRHFFRLCQT SSKNLLNARS LAEIFSPLLF KFQLGSSDNA EHLVKILEVL ITSEWNERQP
VPALPPKPPK PNTVINNGMN NNMSLQDAEW YWGDISREEV NEKLRDTADG TFLVRDASTK
MHGDYTLTLR KGGNNKLIKI FHRDGKYGFS DPLTFNSVVE LINHYRNESL AQYNPKLDVK
LLYPVSKYQQ DQVVKEDSIE AVGKKLHEYN TQFQEKSREY DRLYEDYTRT SQEIQMKRTA
IEAFNETIKI FEEQCQTQER YSKEYIEKFK REGNEKEIQR IMHNYEKLKS RISEIVDSRR
RLEEDLKKQA AEYREIDKRM NSIKPDLIQL RKTRDQYLM
//
