ID A0A4E0R555_FASHE Unreviewed; 1000 AA.
AC A0A4E0R555;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein {ECO:0000259|Pfam:PF07699};
GN ORFNames=D915_008823 {ECO:0000313|EMBL:THD20531.1};
OS Fasciola hepatica (Liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC Fasciola.
OX NCBI_TaxID=6192 {ECO:0000313|EMBL:THD20531.1, ECO:0000313|Proteomes:UP000230066};
RN [1] {ECO:0000313|EMBL:THD20531.1, ECO:0000313|Proteomes:UP000230066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Choi Y.-J., Martin J., Mitreva M.;
RT "Improved annotation for the trematode Fasciola hepatica.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THD20531.1}.
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DR EMBL; JXXN02004520; THD20531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4E0R555; -.
DR Proteomes; UP000230066; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230066};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 919..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 816..853
FT /note="Tyrosine-protein kinase ephrin type A/B receptor-
FT like"
FT /evidence="ECO:0000259|Pfam:PF07699"
FT REGION 829..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 114515 MW; 0A7FCF1F4F684047 CRC64;
MQSSVVVHSW RMGQTSDKRM IRFWYQSVQW SVVLICAYGL CSTSNGLEDE DCAMGLSSMK
QTIRLVDSGD GFTEMVPPEP QLIHIWPNER AILFYQANRP TTQNKVWLYT PPGQEFGYRL
KESVSCIEQG TRYIPDPHEE TFWINTSESG SYMFAEYDTN WKLAKTTGKH YGRNELYNPL
VTFMVLSLEP ANIGLTLKMT QFEPFENCTG ANEKTEWVFR TLFNMRMFRS VRTDKAMLDG
NLTHKVIETK CHLLSDDESP VEIFAYYNID RTRITSNGVQ AHKERKWAVK DKQLDDIQFR
DRKEITLPQP FGAGVRIRLV DIILPPISGL RITLITRSEE GMSEGFWGPG NVEPPFPDEQ
IMPYPFAVVD LNRTIFHQLL ANNKSILDWM LIEPYYGRLR TSTGLMVPFN VKDRWVNGQF
LTALKFEAIG NEADPINIRH IIYERPQHPT DVGEILRVLH TERPLPGATP LHGRACLSTV
HGYYTSTYHV NLEKPSQCIE LDKTDHRVYK KTGSPRSPLT SYSIQLLYDD FGDELENATG
VVTGHVQMIS FPRKHQTHLT EFFCPMRTIG EDGEVMRIGF VVGRNEDVQY ISRWENRWVR
YHSTTGKVFH MELEGQDRIA ESLPGFCGPE RSSIDFVYNL ETKYLQVVAN DTRHTLVNVT
LSRHPMWLGL EMFTDPKVPR CEGCYVNVFI DRRGVHLPYA TRWPTVDSSI NDWNQIQYPK
QYNSKALNIE VVNVVQKFEI RSALFPSPKN LQRRLIELTR KLANSVNISV TVLEANAHCP
PGQYMPYGTP AVCVKCPPGT RSQKLTQNTS FPVYVCDLCP RGMYQDQPGQ EDCKRCDPRQ
STPRKGSWSR GSCGPNVTTD GIFVAQSGGM PAKGEPYVMV ELPSSSKEQI YDWTTHAEEK
EFQTIEGPGE LNMVSTGRLV FNMISLVLLL GCVMAFVVTS KGYMLIWITQ RTRYRFHALE
GSRRDQTRSS ASKKLLWPSQ ETSADTQQRT LESNRSFSVQ
//
