ID   A0A4E0R9D6_FASHE        Unreviewed;       387 AA.
AC   A0A4E0R9D6;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=Traf and tnf receptor associated protein {ECO:0000313|EMBL:THD25239.1};
GN   ORFNames=D915_004083 {ECO:0000313|EMBL:THD25239.1};
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192 {ECO:0000313|EMBL:THD25239.1, ECO:0000313|Proteomes:UP000230066};
RN   [1] {ECO:0000313|EMBL:THD25239.1, ECO:0000313|Proteomes:UP000230066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Choi Y.-J., Martin J., Mitreva M.;
RT   "Improved annotation for the trematode Fasciola hepatica.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC       {ECO:0000256|ARBA:ARBA00004322}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:THD25239.1}.
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DR   EMBL; JXXN02001227; THD25239.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4E0R9D6; -.
DR   Proteomes; UP000230066; Unassembled WGS sequence.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09080; TDP2; 1.
DR   CDD; cd14672; UBA_ceTYDP2_like; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF14555; UBA_4; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
PE   4: Predicted;
KW   Receptor {ECO:0000313|EMBL:THD25239.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230066}.
FT   DOMAIN          100..371
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
SQ   SEQUENCE   387 AA;  43694 MW;  1F6A041BDE433F4D CRC64;
     MPKRKHSPTP PLSDTTRDHE YLSLCSQFAE ITSTNNALAM AFLQDRDWDL ERALADFFAE
     HRTEEPSVQI DHIDLTETSS EDVPTTLESN AVECTVFNVL SWNVDGLDTS NIVQRTDEIV
     SRLKSEPFHV VCFQEVTMVT LPMFRTKLEK DYLIFSPTDL PFSDCVHYFV TIMVRRHPAI
     EVDRNSFLVH SFPNSVMGRH LVSIKLNINS AKLTDQPTPS TTISVRIFTA HLESCRESSA
     ERKNQLAYAW TRMKYFGPPS ENASNEHPRA SIFCGDLNLR DKEVEELGGV PPDITDVWLA
     TGSRLELCAT WDPRRNTNAS RLVGGGPRRY GSSPIFRYDR MYVHGAGLKP VDFGLRGLEK
     VPGAACFPSD HWGILGRFQL DTVSHTS
//