ID   A0A4E0RDG2_FASHE        Unreviewed;       849 AA.
AC   A0A4E0RDG2;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   03-MAY-2023, entry version 12.
DE   SubName: Full=Serine incorporator 5 {ECO:0000313|EMBL:THD24665.1};
GN   ORFNames=D915_004703 {ECO:0000313|EMBL:THD24665.1};
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192 {ECO:0000313|EMBL:THD24665.1, ECO:0000313|Proteomes:UP000230066};
RN   [1] {ECO:0000313|EMBL:THD24665.1, ECO:0000313|Proteomes:UP000230066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Choi Y.-J., Martin J., Mitreva M.;
RT   "Improved annotation for the trematode Fasciola hepatica.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TDE1 family.
CC       {ECO:0000256|ARBA:ARBA00006665}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:THD24665.1}.
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DR   EMBL; JXXN02001485; THD24665.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4E0RDG2; -.
DR   Proteomes; UP000230066; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR   PANTHER; PTHR10383:SF9; TMS1, ISOFORM F; 1.
DR   Pfam; PF03348; Serinc; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230066};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        182..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        758..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        797..819
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          396..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          576..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..490
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  94775 MW;  6FE64FFADB394FC7 CRC64;
     MSCACGPLPC CISLCKNVRE STTTRLLYTI ILFVVVVLSL LSHESGWMGK IYSQFQEDLD
     NFCSKLNAGT GCRRLAGFIA IYRLCFPLFV FHFLMTFLMT GVSSSQTIRG KIHNGFWFWK
     ILFLVLLYIL AYSFPVLEKW TKIWMIIGII GGLMFVYIQH ITLIDFAYEI NGIWHAKAAK
     SVGFAVCIYA VTLVLYLATA GAYACFIIFY GLPQQCSLNL TVTGVNGGLT ALLAICSVFS
     NTLRRKQLWL PGAVTSAFVA FLTWSALGSQ PRVLSSDVPW QNRAVSSMDK KINATMHPLL
     VAADHLNRLL SDQFQPQSDQ SSVVRGPTVT SPTVMINQCL PGGISSLSDH LGKDIFMVLG
     LLLVIGGSLY SSVRATMQAR RMGIRTHRER LKMLLSPIPE QPELVDRAPP TSAGISDNPE
     PDPDEEYISK KKIKQQERRD DMTLNRLAET VAALPNPKVF RRPSARQPSR RTRNGTRKAI
     SPTSPPNGGV TRAELSYEDG VPLIGPAVTS PDPLTHSTLR VASSVPDLSS TMRRLSRAAA
     QRTDITQVQW NPLPPSSTDQ SNYAPLPTYH EIIFEDTFGN PPRTSAQTKR VAKRQRKGTI
     RPSDLGKPLS RAGRIGDRQT RRTKEEQLAM KLARLAPDAF PDRNAEPNRS SMIEITFPDR
     PNGQLIPAAK RPSQSRLSTG DLPDLILDEG DTIGWSSPNH IRYRRARSVT ELVVTPRAIR
     LLESQPNLVH SLAYLKPMLD KEAPRDGYVI YNETIASVYS YPWFHFIYAL SSLYLMTQLT
     NWYNPQISRV ETLSESWATM WMKLASSWLA LLLYAWTIAC PRLCIGRKLG DTPFTVRTPN
     SHRSTPSSV
//