ID   A0A4E0RPH2_9GAMM        Unreviewed;       915 AA.
AC   A0A4E0RPH2;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=CoA-binding protein {ECO:0000313|EMBL:TGO02364.1};
GN   ORFNames=PN36_26185 {ECO:0000313|EMBL:TGO02364.1};
OS   Candidatus Thiomargarita nelsonii.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Thiotrichaceae; Thiomargarita.
OX   NCBI_TaxID=1003181 {ECO:0000313|EMBL:TGO02364.1, ECO:0000313|Proteomes:UP000030428};
RN   [1] {ECO:0000313|EMBL:TGO02364.1, ECO:0000313|Proteomes:UP000030428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hydrate Ridge {ECO:0000313|EMBL:TGO02364.1};
RX   PubMed=27199933; DOI=10.3389/fmicb.2016.00603;
RA   Flood B.E., Fliss P., Jones D.S., Dick G.J., Jain S., Kaster A.K.,
RA   Winkel M., Mussmann M., Bailey J.;
RT   "Single-Cell (Meta-)Genomics of a Dimorphic Candidatus Thiomargarita
RT   nelsonii Reveals Genomic Plasticity.";
RL   Front. Microbiol. 7:603-603(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TGO02364.1}.
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DR   EMBL; JSZA02000152; TGO02364.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4E0RPH2; -.
DR   Proteomes; UP000030428; Unassembled WGS sequence.
DR   GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 1.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032875; Succ_CoA_lig_flav_dom.
DR   InterPro; IPR016102; Succinyl-CoA_synth-like.
DR   PANTHER; PTHR11117:SF2; SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11117; SUCCINYL-COA LIGASE SUBUNIT ALPHA; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF13607; Succ_CoA_lig; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030428}.
FT   DOMAIN          27..131
FT                   /note="CoA-binding"
FT                   /evidence="ECO:0000259|SMART:SM00881"
SQ   SEQUENCE   915 AA;  99149 MW;  8B1B3D172174D0BB CRC64;
     MTENSSYSKG VDAFPHFYVG INSLAELATK EDRVCVLNIL GSESRGVTPT SHVYSGGNIV
     CGTMPGRSGS VLKTKIGDIP VYNNVTEALE AGHQFNVAVV YVPPSGVKDA VIEAVRVNPA
     INKVIILTEK VALSDARIIR QYGQRHNVDV FGANCLGIAD AHQHVRIGGA LGGSSPEESL
     VPGSIAIFSN SGNFTTTMAT YILTAGWGTT ISYSSGKDVY IHFAAAEFTH AFHNDDRSKA
     ALMYIEPGGY YEHDLEFKKP VVACVVGRWK DKLTRACGHA GAMAGSGDNA GEKERWFMNK
     LGVNDIYSPE NPVHSAKGAV VTNIAHLPEA LTAVMKANGV EPDFEPKGNL SLKPWLGNNQ
     DIALPSNLDI DLVEAISPYK EQLELLTKQL GIALPRQTMK DASGASMMDP KTQVSKLYGV
     SVLDAALHTY EDNLVMSLVQ KYPDENGRAL ANLALNAFVN QHNTPALMAA EASREAGNSP
     NTVLSSSMAI LGPKTAETAR KAVRILLNLF KGSELVNPSE TSFDFSKQLS AVLADDEAKA
     VLVSSEGDQC GQMIFDAARN GGAKSVFLDF LEELAKQSGA KLEGQIVLAA ITCHLGWREL
     VHKRLSMTTM INMPWHFRIF SSIIGTSVAV NRQDKESFCG VSNLELMTSW SFTETAYLAL
     LGKRPDKEAL FAFSVLLGLI VTNGPGTISA QGAKGAVSAD GPEVPERVQL NKAYVGFLTH
     TGYAHGGNGF EAIEFLLHRF KESGLNEPGN DKHGLDLSAM ALEYAKEYKA YKTKAKAEGN
     LSYAKIPCVN HPVFKDKDVN YDPREVFVND LFKKRGAYNI FLEFYHELVQ ALFKTGVSKK
     VYCVNVDAVI AVILLKILWK PYADGEISER ALETAAFTTF LYGRTIGETA EIEDHLNRGR
     NMDTRTAASK CSSVN
//