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Database: UniProt
Entry: A0A4P1RB48_LUPAN
LinkDB: A0A4P1RB48_LUPAN
Original site: A0A4P1RB48_LUPAN 
ID   A0A4P1RB48_LUPAN        Unreviewed;       285 AA.
AC   A0A4P1RB48;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Nicotianamine synthase {ECO:0000256|RuleBase:RU368095};
DE            EC=2.5.1.43 {ECO:0000256|RuleBase:RU368095};
GN   ORFNames=TanjilG_05224 {ECO:0000313|EMBL:OIW06453.1};
OS   Lupinus angustifolius (Narrow-leaved blue lupine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX   NCBI_TaxID=3871 {ECO:0000313|EMBL:OIW06453.1, ECO:0000313|Proteomes:UP000188354};
RN   [1] {ECO:0000313|EMBL:OIW06453.1, ECO:0000313|Proteomes:UP000188354}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. Tanjil {ECO:0000313|Proteomes:UP000188354};
RC   TISSUE=Whole plant {ECO:0000313|EMBL:OIW06453.1};
RX   PubMed=27557478; DOI=10.1111/pbi.12615;
RA   Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA   Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA   Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA   McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT   "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT   an emerging health food: insights into plant-microbe interactions and
RT   legume evolution.";
RL   Plant Biotechnol. J. 15:318-330(2017).
CC   -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC       sensor for the physiological iron status within the plant, and/or might
CC       be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC         methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC         Evidence={ECO:0000256|RuleBase:RU368095};
CC   -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC       {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
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DR   EMBL; CM007368; OIW06453.1; -; Genomic_DNA.
DR   RefSeq; XP_019451605.1; XM_019596060.1.
DR   AlphaFoldDB; A0A4P1RB48; -.
DR   GeneID; 109353704; -.
DR   KEGG; lang:109353704; -.
DR   OrthoDB; 2718460at2759; -.
DR   Proteomes; UP000188354; Chromosome LG08.
DR   GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR004298; Nicotian_synth.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR32266:SF11; NICOTIANAMINE SYNTHASE; 1.
DR   PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR   Pfam; PF03059; NAS; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51142; NAS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000188354};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368095};
KW   Transferase {ECO:0000256|RuleBase:RU368095}.
SQ   SEQUENCE   285 AA;  32024 MW;  33D125905781E63E CRC64;
     MDSIQSLDFF TEISPEIFID QIMKLHARIS KLESPRNSEE VNNLLGNLAK LCSLLPSTTD
     IKDFPKEVLN IRESLNNFTS QAEGLLELES STLISLKPKP LDSVTEYPYY GNYVRIARME
     SKILKAHGME NAKKVAFVGS GAMPLSSILM ALNHMESTHF DNFDIDDKAN EVARRIVASD
     AELEKRMKFE TQDIMEVKER LGQYDCIILA ALVGVNRTAK VKILGHLRVY MKEGGFLVVR
     SAKGARTFIY PSVDVGDLVN FELLTTFQPT HALVHSVLLR KKTKA
//
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