ID A0A4P1REU2_LUPAN Unreviewed; 401 AA.
AC A0A4P1REU2;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 22-FEB-2023, entry version 10.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|RuleBase:RU364141};
GN Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN ORFNames=TanjilG_28241 {ECO:0000313|EMBL:OIW09642.1};
OS Lupinus angustifolius (Narrow-leaved blue lupine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX NCBI_TaxID=3871 {ECO:0000313|EMBL:OIW09642.1, ECO:0000313|Proteomes:UP000188354};
RN [1] {ECO:0000313|EMBL:OIW09642.1, ECO:0000313|Proteomes:UP000188354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Tanjil {ECO:0000313|Proteomes:UP000188354};
RC TISSUE=Whole plant {ECO:0000313|EMBL:OIW09642.1};
RX PubMed=27557478; DOI=10.1111/pbi.12615;
RA Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT an emerging health food: insights into plant-microbe interactions and
RT legume evolution.";
RL Plant Biotechnol. J. 15:318-330(2017).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
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DR EMBL; CM007366; OIW09642.1; -; Genomic_DNA.
DR RefSeq; XP_019446882.1; XM_019591337.1.
DR RefSeq; XP_019446883.1; XM_019591338.1.
DR RefSeq; XP_019446884.1; XM_019591339.1.
DR AlphaFoldDB; A0A4P1REU2; -.
DR STRING; 3871.A0A4P1REU2; -.
DR GeneID; 109350173; -.
DR KEGG; lang:109350173; -.
DR OrthoDB; 473091at2759; -.
DR Proteomes; UP000188354; Chromosome LG06.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000188354};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}.
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..367
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 43949 MW; 598676497AE2B898 CRC64;
MLQHQVVQSP ARLGLTNPNS PSIPNPTPPK LPPSQTHHNQ PHQDRHSTTP SSALLSLLPP
LPRAQALLQQ MASLASKLFE VSSNRSLWIT AFRGSLPTFL SSQGQAHFST QLETSPSSTK
EILSLFTVFQ TQIFEAVAEL QEILDLQDAK QKIDHEIRSK DSALLAFANK LKDAERGLDI
LVDDYSDYRR TKRTKSDGSE DDSLISSTIS SQLKLADILS YAHRISYTTF APPEFGAGLA
PLRGALPPAP QDEQMRASQL YHFADLDIGL PKVETKEKTI EAIIVPPPPQ PVDKNPLADL
SSIQGLLPPN FMVPPGWKPG MPVQLPMDIP IKPPPGWKPG DPVPLPPVDS LPVPRFEELP
HPQIPQPKQP EVIQVQHVNL DLGGTDSSDY SSDDASTDDE D
//
