ID A0A4Q1K5N9_9FLAO Unreviewed; 378 AA.
AC A0A4Q1K5N9;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
GN Name=folK {ECO:0000313|EMBL:RXR21236.1};
GN ORFNames=EQG63_04665 {ECO:0000313|EMBL:RXR21236.1};
OS Flavobacterium amnicola.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2506422 {ECO:0000313|EMBL:RXR21236.1, ECO:0000313|Proteomes:UP000290283};
RN [1] {ECO:0000313|Proteomes:UP000290283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LLJ-11 {ECO:0000313|Proteomes:UP000290283};
RA Chen W.-M.;
RT "Cytophagaceae bacterium strain CAR-16.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXR21236.1}.
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DR EMBL; SBKO01000001; RXR21236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Q1K5N9; -.
DR OrthoDB; 9776634at2; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000290283; Unassembled WGS sequence.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01673; dNK; 1.
DR CDD; cd00483; HPPK; 1.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01498; folK; 1.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01712; dNK; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RXR21236.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290283};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RXR21236.1}.
FT DOMAIN 8..134
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
FT DOMAIN 181..376
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 378 AA; 44065 MW; E981D6386DA32029 CRC64;
MNLQKKVVLS LGSNIGNRLE NIETCIQLVH QRIGLVLRVS QLFETPSWGF ESDAFYNCAV
LIHTSFSAEK ILRKITAIEK EMGRTRKKDA GYEARIIDID IITLEEQIIT TENVTIPHTQ
MQHRKFVLLP FQDLKWEWQH PILNKSIPEL IQTCEDKSDC KIVASLTAPA MNCNVNQINY
IAIEGNIGAG KTTLATKISE DFNAKLVLER FADNPFLPKF YKDQNRYAFP LEMSFLADRY
QQLADDLSQF DLFADFVVAD YHIFKSLIFA KVTLQEDEFR LYKTLFDIIY KEMPKPDLYV
YLYQNTERLL KNIKKRGRSY EQEIPAEYLD KINQGYLDYI KTQTDLNVLV IDVSDFDFVK
RQEDYITILQ AIQEKLDC
//
