ID A0A4Q1ZVT2_9FIRM Unreviewed; 446 AA.
AC A0A4Q1ZVT2;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:RXV60020.1};
GN ORFNames=DWB64_14010 {ECO:0000313|EMBL:RXV60020.1};
OS Fusibacter sp. A1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XII. Incertae Sedis; Fusibacter.
OX NCBI_TaxID=2283630 {ECO:0000313|EMBL:RXV60020.1, ECO:0000313|Proteomes:UP000290764};
RN [1] {ECO:0000313|EMBL:RXV60020.1, ECO:0000313|Proteomes:UP000290764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A1 {ECO:0000313|EMBL:RXV60020.1,
RC ECO:0000313|Proteomes:UP000290764};
RA Yadav S., Villanueva L., Damste J.S.S.;
RT "Draft genome sequence of Fusibacter sp. A1 isolated from Black Sea.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXV60020.1}.
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DR EMBL; QQWI01000009; RXV60020.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Q1ZVT2; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000290764; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21147; RsmF_methylt_CTD1; 1.
DR Gene3D; 2.30.130.60; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR031341; Methyltr_RsmF_N.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR027391; Nol1_Nop2_Fmu_2.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR031340; RsmF_methylt_CI.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF17125; Methyltr_RsmF_N; 1.
DR Pfam; PF13636; Methyltranf_PUA; 1.
DR Pfam; PF17126; RsmF_methylt_CI; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000290764};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 22..298
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 231
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 109..115
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 133
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 178
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 446 AA; 50281 MW; 9C79090506951A1C CRC64;
MHLPEKFISQ MKDVFGNDFD AYLASFSLPR EAGLRVNLNK ITPEEFEKIC PFKLERIPWT
TDGYYVDPDL RPAKHPFYHA GLYYMQEPSA MAPVNTMHIE NGERILDLCS APGGKTLQIA
NRVGESGLVV SNDISASRLR AVVKNIEQFG LKNVIITSEQ VDKLANLQRE FYDRILVDAP
CSGEGMFRKD PSIAASWSEA SNDEYHAIQS SLAEGVQPML KGGGQFLYST CTFSPVENES
VIEGLLNAHS ELTIEDIDSE YFEDGIAIGG DERLRSAKRL YPFKLRGEGH FLASLIKDGR
LEANVNPQKD QPAPEELQAF MKEVLHEPIV GSFRVHNDKI LLDPQAVPDL KGIRVLRRGW
LLGELVKGRF EPAQSFAMGL KKEWIKNTIT FGYEEIEVVK YLKCETLHVD YPNGWYVVCM
GDFPLGWAKV VNGQLKNKYP AAWRMV
//
