ID   A0A4Q4UD60_9PEZI        Unreviewed;       662 AA.
AC   A0A4Q4UD60;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN   ORFNames=DL766_008696 {ECO:0000313|EMBL:RYP18325.1};
OS   Monosporascus sp. MC13-8B.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariales incertae sedis; Monosporascus.
OX   NCBI_TaxID=2211646 {ECO:0000313|EMBL:RYP18325.1, ECO:0000313|Proteomes:UP000292509};
RN   [1] {ECO:0000313|EMBL:RYP18325.1, ECO:0000313|Proteomes:UP000292509}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC13-8B {ECO:0000313|EMBL:RYP18325.1,
RC   ECO:0000313|Proteomes:UP000292509};
RA   Robinson A.J., Natvig D.O.;
RT   "Complete Genomes of Monosporascus.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC         ChEBI:CHEBI:57924; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000426};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC         ChEBI:CHEBI:58315; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001038};
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RYP18325.1}.
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DR   EMBL; QJNW01000474; RYP18325.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Q4UD60; -.
DR   STRING; 2211646.A0A4Q4UD60; -.
DR   Proteomes; UP000292509; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.310.20; -; 1.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR041640; Tyrosinase_C.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF32; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF18132; Tyosinase_C; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000292509};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..662
FT                   /note="tyrosinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5020352452"
FT   DOMAIN          126..144
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          331..342
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
FT   REGION          638..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  74013 MW;  920267A0CF9C89EE CRC64;
     MLPFRFAILL SAWLVPTRPA SLSGRRQYDY GSDVHARFQK RQDYRPPIVT GLPSVDDHLP
     SRREIRELEK DEDLWNLFLL ALSWMQYTDQ DVWSSWYKIA GIHGAPGQTW GGVEAVPGND
     NIGYCHHVSI LFPTWHRPYL ALYEQIMYNI VQYIASLYPP EKREHIGKAA KSFRLPYWDW
     AATPPNGTGV LPLSMGGHPN IAVSGPNGVQ TIANPLFSYT FKPFNASIFP EIPFNTWNET
     KRAPRPINSP AATSNNSFIA RALDSQMPSL QQRLYNLFAN YPNYTSFSNE AWIPTDNNGT
     YDSIEALHDS IHTLGGGAFG HLSIIQYSAF DPLFLLHHVN VDRIFAMWQV LYNDSYVVPM
     PAIYPSHTST AGQIQDAETA LTPFFSGNGT FWNSDTVRDH EVFGYTYPEV SNKNRVEVVA
     SINRLYTHYS PATVAMTYQR RQPRDYGNTA VTDNSRSRPD AYRRSLGLPI DAVFDGEDYY
     EWIANIRVKK DALNDSFMIH LFLGTAPGDP STWTVASNLV GTLGVFAHSG PHGEMGQRHI
     AGTIPMTSAL LDAIAAREIV SLRPRHVEPF LKSQLSLRIS LLTETVASPE EVDGLGVSIC
     RLYLVSDLSL MGVMTAQQWK HGRLPAADLA EDLAEDLAAD PARPPFAESL PTGDDPLFSE
     SP
//