ID A0A4Q4VSZ0_9PEZI Unreviewed; 1045 AA.
AC A0A4Q4VSZ0;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=DL767_002975 {ECO:0000313|EMBL:RYP37332.1};
OS Monosporascus sp. MG133.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Xylariales incertae sedis; Monosporascus.
OX NCBI_TaxID=2211645 {ECO:0000313|EMBL:RYP37332.1, ECO:0000313|Proteomes:UP000293831};
RN [1] {ECO:0000313|EMBL:RYP37332.1, ECO:0000313|Proteomes:UP000293831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MG133 {ECO:0000313|EMBL:RYP37332.1,
RC ECO:0000313|Proteomes:UP000293831};
RA Robinson A.J., Natvig D.O.;
RT "Complete Genomes of Monosporascus.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RYP37332.1}.
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DR EMBL; QJNX01000067; RYP37332.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Q4VSZ0; -.
DR STRING; 2211645.A0A4Q4VSZ0; -.
DR Proteomes; UP000293831; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000293831};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 66..107
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..209
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 730..968
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 430..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 113959 MW; 98C71A6883C6FDD5 CRC64;
MRIIKPSWLS HKGEHKDFEV YSCHVSPDGK RLATAGGDGH VRVWSTEAIY NAEDRSYTKP
KQLCHMSHHL GTIHSVRFSP NGRYLASGAD DKLICIYQLE SGPPAIATFG TNEPPPVENW
KTYKRLVGHD NDVQDLAWSY DGSVLVSVGL DSKIVVWSGH TFEKLKVLSI HQSHVKGITF
DPANKFFATA SDDRTIKIFR FTSPAPNATQ HDMVNNFHLE TTISTPFKSS PLTTYFRRCS
WSPDGNHIAA ANAVNGPVSS VAIIERSRWD SEINLIGHEG PTEVCMFSPR LFHTKKPAEN
GMTNGHSSGG SLVTVIASAG QDKTLSIWNT NTSRPVVILQ DLAAKSISDL AWTPDGQTLF
ASSLDGGIVC AKFETGELGW VANLEETDKA LSKYGTSRKA MAIAEDVDGL QLENHSKEGE
RKGAESRMGA LMGGFHPLPK DGTPTTNGAK TGTATPNQVP ASGQAEAEAE KEKVVPAPEP
ESADKTAQRV NELKSRVTIT KDGKKRVAPM LISSSGTGQS SLPQTQLVGS NSSKTAQNDA
PQTILDLSKP YDGLPEGGLA AMLLGNKRKA AVFEGDGDEE HSNKRQATNA RPIMLNGVDG
LEPATLEPQR HGLVPTPEYL RPAVLNPSIS VSQVRLAVPK VRSHILRPLE RGVLLEDTTL
EEASKVPENI ILEAKNPPSV RDPSHITATK RGTLLWQDYL PRAVILLTGN KKFWAAACED
ATVHTWTPAG RRLINPILLE AQPVILECRD WWLLCITAAG MCFVWNIHTM SSPHPPVSLG
PVLDIAIHSL HPHGTTPAPG VTSAHLNSNG NVVVTLTNGD GYYYSHSMYS WQRLSEPWWA
VGSQYWNSND SSVSALQTTA VGPAATEEAK GDQATVSAGI IPYLERHTTN EFLLKGRAYT
LQRLIKALLS KDGFESFEST VSIAHLENRI AGALSLGSKD EFRLYLLMYA KRIGAEGLRG
KVEELLNLLL GGVLQDKKDK GDRGGSGWFS KDETICGWDR KELLKGVVMI LGKFRELQRL
TVQYARILDL THEDDENGDA MAIES
//
