ID   A0A4Q4YEK4_9PEZI        Unreviewed;       328 AA.
AC   A0A4Q4YEK4;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   RecName: Full=L-threo-3-deoxy-hexylosonate aldolase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DL771_004388 {ECO:0000313|EMBL:RYP72154.1};
OS   Monosporascus sp. 5C6A.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariales incertae sedis; Monosporascus.
OX   NCBI_TaxID=2211642 {ECO:0000313|EMBL:RYP72154.1, ECO:0000313|Proteomes:UP000292526};
RN   [1] {ECO:0000313|EMBL:RYP72154.1, ECO:0000313|Proteomes:UP000292526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5C6A {ECO:0000313|EMBL:RYP72154.1,
RC   ECO:0000313|Proteomes:UP000292526};
RA   Robinson A.J., Natvig D.O.;
RT   "Complete Genomes of Monosporascus.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RYP72154.1}.
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DR   EMBL; QJOB01000063; RYP72154.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Q4YEK4; -.
DR   STRING; 2211642.A0A4Q4YEK4; -.
DR   Proteomes; UP000292526; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   PANTHER; PTHR12128:SF24; DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920); 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000292526}.
FT   ACT_SITE        158
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        187
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         237
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   328 AA;  34961 MW;  390CD27C201CDB7E CRC64;
     MTVANGDASH GHTTARRPLP CGIYAPTMTF FDAQTEELDI PTIKRHAVRL AEAGLAGLTV
     MGSNGEAAHC SREEKVAAVR ATREALDEAG FTQTPIMVGA TEGSVKGTVE LVKESAKAGA
     DYVLLLPPSY YRAQTDEETI EGYFVAVADV SPLPLILYNY PGAVSGIDMD SDLLIRLAQH
     PNIVGTKFTC GNTGKLTRVA LAVDAKTPRS EGSGYMAFGG MCDFTVQTLV SGGSGIIAGG
     ANVMPKVCVK VWNLYAEGKT EEAIALQKVL SRGDWFLTKA AIAGTKQAIQ SYYGYGGYPR
     RPLKRLDEAK VAFIADGIKE VMEVEKKL
//