ID   A0A4Q7ZLM9_9ACTN        Unreviewed;       339 AA.
AC   A0A4Q7ZLM9;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   28-JUN-2023, entry version 11.
DE   SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:RZU51225.1};
GN   ORFNames=EV385_3034 {ECO:0000313|EMBL:RZU51225.1};
OS   Krasilnikovia cinnamomea.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Krasilnikovia.
OX   NCBI_TaxID=349313 {ECO:0000313|EMBL:RZU51225.1, ECO:0000313|Proteomes:UP000292564};
RN   [1] {ECO:0000313|EMBL:RZU51225.1, ECO:0000313|Proteomes:UP000292564}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45162 {ECO:0000313|EMBL:RZU51225.1,
RC   ECO:0000313|Proteomes:UP000292564};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RZU51225.1}.
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DR   EMBL; SHKY01000001; RZU51225.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Q7ZLM9; -.
DR   OrthoDB; 9774633at2; -.
DR   Proteomes; UP000292564; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000292564};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          13..240
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
SQ   SEQUENCE   339 AA;  37220 MW;  9BC4FEC2BAB11984 CRC64;
     MLTPAEFATF TEAYTAVLRH LLDHPEYKTA GRGKDALEVP NISFRLTNAI QRTPYLAARR
     ANIAFNYAEL LWYVAGRDDI TMISYYAPRL AKLSTDGLTL TGTAYGPRLF RPDGPDGLSQ
     FDRCVKALEQ DRDSKRAAMI IMRPHEAIGP DNPDVACTLG LQFMLRGGRL HATGYMRGND
     AVIGLLCDTF SFTMIQELAA RRLGVPVGSY THHVGSMHIN VLDREKVAAI LAEADAGPAP
     RFPAPQMPGL SSAELELLLQ WEAVLRAGAG ELTGDTVTAL PLPHYWQQAL LVFQAYQQVQ
     AGHPVTTDIA AALTPAHRWL LAARWPDRIT ADYPPTTPS
//