ID A0A4R1ALL9_9ACTN Unreviewed; 630 AA.
AC A0A4R1ALL9;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=MBL fold metallo-hydrolase {ECO:0000313|EMBL:TCI97616.1};
GN ORFNames=E0W78_11225 {ECO:0000313|EMBL:TCI97616.1};
OS Aeromicrobium sp. IC_218.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=2545468 {ECO:0000313|EMBL:TCI97616.1, ECO:0000313|Proteomes:UP000293071};
RN [1] {ECO:0000313|EMBL:TCI97616.1, ECO:0000313|Proteomes:UP000293071}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IC_218 {ECO:0000313|EMBL:TCI97616.1,
RC ECO:0000313|Proteomes:UP000293071};
RA Johnsen N., Bonefeld L., Nazipi S., Marshall I.P.G., Schramm A.;
RT "High quality draft genome sequence of Aeromicrobium massiliense IC_218,
RT isolated from nest material.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Type III
CC sulfatase family. {ECO:0000256|ARBA:ARBA00033751}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TCI97616.1}.
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DR EMBL; SJXM01000009; TCI97616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4R1ALL9; -.
DR OrthoDB; 5240502at2; -.
DR Proteomes; UP000293071; Unassembled WGS sequence.
DR GO; GO:0018741; F:linear primary-alkylsulfatase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0018909; P:dodecyl sulfate metabolic process; IEA:InterPro.
DR CDD; cd07710; arylsulfatase_Sdsa1-like_MBL-fold; 1.
DR Gene3D; 1.25.40.880; Alkyl sulfatase, dimerisation domain; 1.
DR Gene3D; 3.60.15.30; Metallo-beta-lactamase domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR038536; Alkyl/aryl-sulf_dimr_sf.
DR InterPro; IPR029229; Alkyl_sulf_C.
DR InterPro; IPR029228; Alkyl_sulf_dimr.
DR InterPro; IPR044097; Bds1/SdsA1_MBL-fold.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR PANTHER; PTHR43223; ALKYL/ARYL-SULFATASE; 1.
DR PANTHER; PTHR43223:SF1; ALKYL_ARYL-SULFATASE BDS1; 1.
DR Pfam; PF14864; Alkyl_sulf_C; 1.
DR Pfam; PF14863; Alkyl_sulf_dimr; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:TCI97616.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000293071};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 103..325
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 630 AA; 67662 MW; 2C24A950AEEE5DC4 CRC64;
MTTAPKDASP AVVAQQRAVL DTLPFSDVRD FDAVRRGLVA RREPNAVTAE DGRVVWDNDT
YGFLTGDAPD TVNPSLWRQS TLVAADGLFE VVPGVYQVRG LDLSNISFVE GDTGVIVIDP
LISTETAAAA LDLYREHRGD RPVTGVIYTH SHVDHFGGVK GVTSQEDVDA GRVPVLAPEG
FVEHAVAENV YAGTAMGRRA GYMYGAALPR SPRGALGAGL GQTTSTGTVT LIAPTVEITT
TGQEEVVDGV RIVFQMAPDT EAPSEMLFYF PDLKALCAAE DATHTLHNLL TLRGALVRDP
HVWSTYLTET LDLFGAEVEI VFASHHWPTW GNADVVEFLT LQRDLYAYLH DQTLRMLNQG
LTGSEIAEQI TLPPALEDAW STRGYYGSVS HDVKAIYQRY MGWFDGNPAH LWEHTPVEKA
VRYVALGGGA DAVVAHGRDA LEAGDLRWAA EVLSHVVFAE PDHPTARELL ADTLEQLGYG
AENGTWRNFY LSGAYELRNG GFGTPTVTAS PDMVAELSPG MLFDALAVQV DGPAAWDERL
TIDVVLTDAD ERYRLRLAHG VLVHSAAPQT GAPDATLTTT RRGLTALATG PLTSERLTAA
GIAVDGDASA LTRLAAVLDP GDPDFAIVTP
//
