ID   A0A4R1UHS8_9SPHN        Unreviewed;       304 AA.
AC   A0A4R1UHS8;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:TCM15713.1};
GN   ORFNames=EDF56_10943 {ECO:0000313|EMBL:TCM15713.1};
OS   Novosphingobium sp. PhB165.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=2485105 {ECO:0000313|EMBL:TCM15713.1, ECO:0000313|Proteomes:UP000295319};
RN   [1] {ECO:0000313|EMBL:TCM15713.1, ECO:0000313|Proteomes:UP000295319}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PhB165 {ECO:0000313|EMBL:TCM15713.1,
RC   ECO:0000313|Proteomes:UP000295319};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-V): Genome sequencing
RT   to study the core and pangenomes of soil and plant-associated
RT   prokaryotes.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TCM15713.1}.
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DR   EMBL; SLVB01000009; TCM15713.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4R1UHS8; -.
DR   OrthoDB; 9778880at2; -.
DR   Proteomes; UP000295319; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000295319}.
FT   ACT_SITE        136
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        164
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         206
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   304 AA;  33269 MW;  4FC22554CC2343A3 CRC64;
     MAIAWKGVFP AVTTQIREDL SLDLADTQRV VDDLINDGVT GVIALGTVGE NNSLEYDEKV
     QVLTAIVEAV NGRVPVVTGV SEFDTRRAVR YAQAAEKAGA DGLMLLPPMV YVPKAKELVA
     HFKGVADQTG LPIMLYNNPP AYRTVIDKDV LTALIDVKNI VAVKESAPDT RRFTDFRNTF
     GDRYTLFAGL DDVALEGLYL GAQGWVSGLT NAFPKESVEL VKAFERGDHA KAMEIYRWFM
     PLLHLDAEHD LVQSIKLAEQ VMGRGSERVL PPRYVLEGER RAEVIAMVEK AAATRPDLTV
     AAAA
//