ID A0A4R5C327_9ACTN Unreviewed; 676 AA.
AC A0A4R5C327;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=E1293_00370 {ECO:0000313|EMBL:TDD92959.1};
OS Actinomadura darangshiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=705336 {ECO:0000313|EMBL:TDD92959.1, ECO:0000313|Proteomes:UP000295578};
RN [1] {ECO:0000313|EMBL:TDD92959.1, ECO:0000313|Proteomes:UP000295578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45941 {ECO:0000313|EMBL:TDD92959.1,
RC ECO:0000313|Proteomes:UP000295578};
RA Sahin N., Ay H., Saygin H.;
RT "Draft genome sequences of novel Actinobacteria.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDD92959.1}.
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DR EMBL; SMKY01000001; TDD92959.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4R5C327; -.
DR OrthoDB; 155383at2; -.
DR Proteomes; UP000295578; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF13570; PQQ_3; 2.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:TDD92959.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000295578};
KW Transferase {ECO:0000313|EMBL:TDD92959.1}.
FT DOMAIN 20..280
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 676 AA; 70273 MW; 2185FD4F48B3690B CRC64;
MSEETMAPLE PEDPREVGGY RLLGRLGAGG MGQVFLGRSA SGLTVAVKVI HARYADDPKF
RARFRREVGT ARAVSGAFTA SVIDADADAS SPWLVTTFLE GRPLNEAVAE HGPLPPPAVA
ALGAGLAEAL ISIHRAGIVH RDLKPHNVML SPDGPRVIDF GIAHAEDISA ITRTGAVIGS
PGYMSPEQAR GNGTGPPGDV FSLGAVLAFA ATGTGPFGRA QMQIMVYRVV HEEPDLGGVT
DPRLRSIIAA CLDKDPSRRP APRLLLHWLG TAAPQGVAWL PPPMAASIAQ ATTQVAVGRK
PIGRRVLLSG GAGAVALAAT GAVAAAVLDA PEKAKAPDGR LVRTFATGGA VAADPILADA
GRRVIVGSDS GRLVAFDTRN GSQIWSYPEK ADRQAPFKAA PAGTGPALYA VSGDGRLHAV
DAASGRGLWT TTHTDHVTGT VPVLGDRLIF VLTGSTAENK AVNVYDPEGR LKGQIPNVMG
APTAGRSHSG EALVYLSVLG GVAAYDAGTG RLKEQASSQA PISSVLLKGG NGILYGIDIQ
GQIWAYSPRD NSQIWGPRRP GGSDKALPAG LPEISGSEAY VTDKDGFLYA VDADSEWTAP
KWTFRADAPF DTAPRSDGKL VYAVSTDGYL HAVNRVGGKE VWRFRTAGNG RARPVFHGDT
VYVGGTNGLH AIRPPA
//
