ID   A0A4R5DR51_9BACT        Unreviewed;       313 AA.
AC   A0A4R5DR51;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Dihydrodipicolinate synthetase {ECO:0000313|EMBL:TDE14690.1};
GN   ORFNames=E0F88_16005 {ECO:0000313|EMBL:TDE14690.1};
OS   Dyadobacter psychrotolerans.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC   Dyadobacter.
OX   NCBI_TaxID=2541721 {ECO:0000313|EMBL:TDE14690.1, ECO:0000313|Proteomes:UP000294850};
RN   [1] {ECO:0000313|EMBL:TDE14690.1, ECO:0000313|Proteomes:UP000294850}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR-3-6 {ECO:0000313|EMBL:TDE14690.1,
RC   ECO:0000313|Proteomes:UP000294850};
RA   Chaudhary D.K.;
RT   "Dyadobacter AR-3-6 sp. nov., isolated from arctic soil.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TDE14690.1}.
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DR   EMBL; SMFL01000005; TDE14690.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4R5DR51; -.
DR   OrthoDB; 9778880at2; -.
DR   Proteomes; UP000294850; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   PANTHER; PTHR12128:SF21; N-ACETYLNEURAMINATE LYASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000294850}.
FT   ACT_SITE        140
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        170
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         48
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT   BINDING         212
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   313 AA;  34463 MW;  3BE60C6E1F6256F0 CRC64;
     MKPKLQGLIA APFTPMHADG SINTDLIAAY YEFLKQNQIT GAFICGSTGE GVSMSLTEKK
     QIASAWAECT KLDPDFKVMI LLGGTCIVDC IELAKHAQEV GLYAVSFTSP FYFKPANVEM
     LAQTIISIAE AVPEIPFYYY HIPVLTGVGF AMFDLLKALD GRLDNFAGIK YTHEDFMDFQ
     TCLNYKNGEY DMLWGRDENM LSALAVGAKG AVGSTFNYAA PLYYDLINAF EKHELSRAGA
     LQQKSIDMIR LLGKYGGISV GKAYMKLVGI DCGQFRLPVK NMSEAQSNDF KSDVASLDFD
     TFKSKMDTVN SSL
//