ID A0A4R8RB45_COLTR Unreviewed; 1412 AA.
AC A0A4R8RB45;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN Name=exo2 {ECO:0000313|EMBL:TDZ53605.1};
GN ORFNames=CTRI78_v006868 {ECO:0000313|EMBL:TDZ53605.1};
OS Colletotrichum trifolii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum orbiculare species complex.
OX NCBI_TaxID=5466 {ECO:0000313|EMBL:TDZ53605.1, ECO:0000313|Proteomes:UP000295703};
RN [1] {ECO:0000313|EMBL:TDZ53605.1, ECO:0000313|Proteomes:UP000295703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=543-2 {ECO:0000313|EMBL:TDZ53605.1,
RC ECO:0000313|Proteomes:UP000295703};
RA Gan P., Shirasu K.;
RT "Genome sequence and assembly of Colletotrichum trifolii.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multifunctional protein that exhibits several independent
CC functions at different levels of the cellular processes. 5'-3'
CC exonuclease component of the nonsense-mediated mRNA decay (NMD) which
CC is a highly conserved mRNA degradation pathway, an RNA surveillance
CC system whose role is to identify and rid cells of mRNA with premature
CC termination codons and thus prevents accumulation of potentially
CC harmful truncated proteins. {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDZ53605.1}.
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DR EMBL; RYZW01000068; TDZ53605.1; -; Genomic_DNA.
DR STRING; 5466.A0A4R8RB45; -.
DR Proteomes; UP000295703; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF83; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nonsense-mediated mRNA decay {ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000295703};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..228
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 276..670
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 721..909
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 913..1138
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1156..1226
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1256..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 157829 MW; 92ADB502C0B5ED79 CRC64;
MGVPKFFRWL SERYPAISQL IAENRIPEFD CLYLDMNGII HNCTHKDAGE DTTFRLSEEE
MFIRIFNYIE HLFGKIKPKQ LFFMAIDGVA PRAKMNQQRA RRFRTALDAE KARDQALKDG
VSMPKEPPFD SNCITPGTEF MAKLTQQLKY FVNKKVSEDA DWQGCEIVLS GHEVPGEGEH
KIMEYIRNAK AQPDYDPNVR HCLYGLDADL IMLGLLSHDP HFCLLREEVT FGRSSKNKSK
ELEHQNFYLL HLCIVREYLE LEFQELQEPG KLSFPFDLER VIDDFILMAF FVGNDFLPNL
PRLHINEGAL AAMFRIYKSV LPQGDGYINE GGVINLERLR TLLNELSKDE KTQFEHDVGD
ESWFRSKRLA EDPTGVGNKK PKGKGLVLTS SQRDLWKQKI RAYVNKPSTE PLDLGASLNA
ADRKFVQDLA DTLHIEWSTK EDDDGHRHLL LSFPAGAAEN ANDEEEEGTL ALYRVMRNYD
KALVIDLTAD DAQRHYEELY DRKYLAWKTK YYLEKFPEWS PEVYDTELTK LCENYVQGLQ
WVLYYYYQGI ASWPWYYQYH YSPLTSDVVR GLGANLKFTL GQPFRPFEQL MGVLPDRSKS
IVPEIYWDLM TNPKSPIYDF YPRDFELDMN GKKMEWEAVV KIPFIDEKRL LDAMATKNDQ
LSDDQKSRNG FGVALKFTYN PEIAFTYPSS LPGVFPEIAP CQCVENMFEL PSTDGLDLRK
GLVDGVKINV EALAGFPTLH TLPYTAMLVE GYGVNVFQAD SKNPSMIVTL TDSEMRTRAE
TASQKLGKRC FVGYPFLQEA KIVKVSDELF DYELDEHTGS VVTRNHAPRD IDFFTKESHY
IEHWHAKRLG FTIGPVESLV QVHMLKGLIK TEEGALIKEY AENPSMRSVY ASQTIVDDVV
NEDERFIERA AVPIEEEYPI GTQAFFLGEY SYGRALEVTG HLNNKANIRV LVLKNKEPDF
AKPIIQDMKR QNRYTPSYAV AKMLGLHPLI LSKILSSYQI NTVGGLRVNL GLNLKFDAKK
QKVLGYSQKS ESGWEFSNAA IELLAKYIAA FPDFFAAIQQ NPQSSDVNDT DLWKDPKVAA
QRVKDIGAWL KTAQTSKFER VPLEAEQLDS VVVMRLAEAG AQVFLNSHDV DTKTLKGVPR
SAIMKPSDAE LVLGNQRFAL GDRVSFLSSS GKVPLGSRGT VVGLSRTATN IWLDVVWDLT
FMSGTTLGDR CPPFRGMTVA SSSVLNTTFK QVVSGSKAGQ QRRPIATLTT STALGVPQYS
DAPAPGPLRG SWRGALNGHQ GQNGRGHGRG GGPNLIHSNL VYRLANGAGE GQGVNGQGQR
GGGNPRGRGR GRGGPVQHPG QAGLHEAPGS AQQPMYSNVP PPASLDARGR GRGRGGRGGR
GRGGPRGRGG NGAPNGAVDG ASAGASAAAG QS
//
