ID A0A4S2JA70_9HYME Unreviewed; 1048 AA.
AC A0A4S2JA70;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=DBV15_03803 {ECO:0000313|EMBL:TGZ32010.1};
OS Temnothorax longispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300112 {ECO:0000313|EMBL:TGZ32010.1, ECO:0000313|Proteomes:UP000310200};
RN [1] {ECO:0000313|EMBL:TGZ32010.1, ECO:0000313|Proteomes:UP000310200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:TGZ32010.1};
RX PubMed=30967075;
RA Kaur R., Stoldt M., Jongepier E., Feldmeyer B., Menzel F.,
RA Bornberg-Bauer E., Foitzik S.;
RT "Ant behaviour and brain gene expression of defending hosts depend on the
RT ecological success of the intruding social parasite.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 374:20180192-20180192(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ32010.1}.
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DR EMBL; QBLH01003970; TGZ32010.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S2JA70; -.
DR STRING; 300112.A0A4S2JA70; -.
DR Proteomes; UP000310200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000310200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..644
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 653..1048
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 789..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 116014 MW; 5F54FC1D1FAB9796 CRC64;
MAHENGINGG DTDSESVELN PLRRTRFHVN RVDSLEGRAS LLGEQETKKS LRYMTREALP
RLDNYRNIMS IQAAHRPSLD ELHNPTLLNK GSGSHTLTVP QLKSMAPGVK FGWIQGVLMR
CLLNIWGVML FLRLSWVVAQ TGIGQAILLI LTTTVVTTIT SLSMSAISTN GLIKGGGTYY
MISRSLGPEF GGSIGLIFSL ANAVACSMYV VGFCESLVDC LRPFDACIID CATSDIRIIG
SITIVVLLII VIIGMEWEAK AQILLLIILL VAIGDFIIGT FVGPKSETER AKGFIGYNAK
LFKENLYPNY RSHEGVKHNF FSVLAIFFPA ATGILAGANI SGDLKDPQTA IPKGTLLAIL
LTSLSYLMMA IMVGGTVMRD ASGNVTDLWT TYNSSLLALS MLGADNDTEI ENSTVIENIT
RSWSVYGTDF NCTAGCKYGS HNSFEVIQLV SGFGPIIYAG CFAATISSAL ASLVSAPKVF
QALCLDKLYP GISWFSGEKD KEPIRGYLLT FIIAVAFILI GELNAIAPLI SNFFLAAYTL
INFSTFHASL AKPIGWRPTF KYYNMWLSLA GAILCVSVMF LISWWTALIT LCAVLALYLV
VSYRKPDVNW GSTTQAQTYN NALTAVQQLD RVEEHVKNYR PQLLVLTGAP NVRSSLVDFA
HHITKHQSLF ICGHIIETPI SYKTRNSMMQ NCPSWLRANK IKAFYSLVDN SNFQDGATSL
LQAAGLGKMR PNILLMGYKQ DWATCQRENL NMYFNVMHKA LDMHIAVVLL RLQEGLDCSA
VVGDVEDPRR LSPTSIPGNQ SFSQLSQASS TSDISIPGSP APRRSKTINE YPNPSSEEQR
ENRPNIVPIT NILNVITKFQ RKHKKGTIDV WWLYDDGGLT LLLPYIISTR RNWSNSKLRV
FALANKHSEL EYEQRSVASL LSKFRIDYSA LKVISDISKP AQASTKTFFD SLIADFQETA
DSKNSDDDVI KDSELMAMKE KTNRHLRLRE LLLENSMEAN LVVMTLPMPR KGAVSAPLYM
AWLETLTRDM PPFLLVRGNH TSVLTFYS
//
