ID A0A4S2KCA2_9HYME Unreviewed; 2968 AA.
AC A0A4S2KCA2;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:TGZ46416.1};
GN ORFNames=DBV15_04496 {ECO:0000313|EMBL:TGZ46416.1};
OS Temnothorax longispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300112 {ECO:0000313|EMBL:TGZ46416.1, ECO:0000313|Proteomes:UP000310200};
RN [1] {ECO:0000313|EMBL:TGZ46416.1, ECO:0000313|Proteomes:UP000310200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:TGZ46416.1};
RX PubMed=30967075;
RA Kaur R., Stoldt M., Jongepier E., Feldmeyer B., Menzel F.,
RA Bornberg-Bauer E., Foitzik S.;
RT "Ant behaviour and brain gene expression of defending hosts depend on the
RT ecological success of the intruding social parasite.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 374:20180192-20180192(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ46416.1}.
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DR EMBL; QBLH01002884; TGZ46416.1; -; Genomic_DNA.
DR STRING; 300112.A0A4S2KCA2; -.
DR Proteomes; UP000310200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000310200};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1241..1436
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1576..1734
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2469..2503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2474..2503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2517..2534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2968 AA; 339542 MW; FC2A31C81111E219 CRC64;
MLNLFRIEEV CALTYLIYDI IIFVSFNVDC INMLCYYLIN IYMKNNEGAY VHDIIVNKND
YYLPCRSGPE SPHSRVNEKR CKKCLIEISR YRFSFVISGL TKMLQRVNEL TPSTSSQRPF
QPKDQDRQES IIIVLDTLEK CLANTPKDTT KFEEAMNVKL LLREICQFIG MPYDSPQTKM
IRTLASKVLF ALSLTFFNAV FNRISARLQE LSNSGDENPD CSDIELMQYI NVDVYRLTRL
LNETIQKIRQ LVGKKSAYLV LMNPLEKAIW NWMDTYPQEF ADVQKQPNED LSKACEELFD
ILDTFVVEKK SRAASVWPLQ MMLLVLSPKV LEIVNTDTRP PASPRYSRKK QFIDSVKRSL
RMHGSSSSRQ LSEAAAITCV NLIKAATYVN NAESSNVVLT LAKQLMDDLM SLLFNPSKPF
SRGQTYSAQD VDLMIDFFVS SFRINPHNNE VFKFCLNVTY PSTYQIFTQP RLPWWPERSL
VYSYGTKLRN MFTDTLNKVT QNCMWNTPLR MIHNFALKPK EEMANSKNLL LVMVRLIHVD
PMLMLHSYGT AGHEIQRSTL ELINGLVSLV HQPTMPDIAH EAMEALLVLH HPDKVKAWNP
EAPLDTFWDA SSQVVFSISQ KLIQHQIFNY TTILKWLREI LSCRNAFLSQ YKDYGNVDSH
IAISKQAHIK LEVVCLMYLW SIDMEAVLVS MSCFALLCEE AEILCGSDEV AVTCLLPNYH
VYLDMAQAST VLISAHGESR LCYQEYNHGR AMLQKRILFL LRKIEHCVNG IQPAWEETFR
NWEATSRQLA SYPKSKTEDV QVEPFCRGNV KRRAAHQNSE HEVEEQINEW ANMTGFLCAL
GGVCLQRRSP SRPPYDVFPF NPEHKRGLTK QQDSVLGLTN SNQEAQYCPV TQFVFNLLRL
LICNNEKLGN QIQKHVKELV AHEMSPAVYP ILFDQIKNFV EKSFDPRGHV VVSDLNTQFI
EHTIFIMKNI LDSKTDQPSE YLGVTSIEGM MLAIVRYVRH LDMTLHSICI KTKLCQLVEA
MMKRRDDLAF RQELKFRNKL VEYLTEWVMC THPFSSTTAN DITAYTRDLD QACMEAVGAL
LRGLPLQPED SDRVELMEAK SELFSKYFML FMNLINYCND PSSSSSEDKD LESQQSPTLT
TNKLATLRNT TIQATSNLLS ANIDSGLRHS IHLGYNADLQ TRVAFMEVLT KILQQGTEFD
TLAETVLADR YEQLVQLVTM ISDKGELPIA MALANVVTTN QMDELARVFV TLFDAKHLLS
PLLWNMLYRE VELTDCIQTL FRGNTLGSKI MSFCFKIYGT SYLQGLLEPL IKPLLDEPTI
SFEVDSARID PNESIEQNGD NLITLTQKVF NAIVSSSDTF PPQLRSMCHC LYQVLCKRFP
QSPQSNIVAV GTVIFLRFIN PAIVSPQEMG IVNKPVPYEV KRGLMLMSKI LQNIANHVEF
SKEQHMLPFN DFLRTNFEIG RRFIIQIASD CETVDQTSHP MSFVSDANVL ALHRLLWNHQ
EKIGDYLSSS RDHKAVGRRP FDKMATLLAY LGPPEHKPVD SHSLFSTTYM PMSRWASKDM
SSTNFEEIMM KHNMHEREEF KSIQSMNIFY QAGTSKQGYP VFYYIARRFK LGETNGDLLI
YHVILTLKPF HHSPYDVVVD FTHTCIDNRF RVEFLQKWFC VLPVATYENL HAVYIYNCNT
WVREFTKYYD SIVAPLKGCR KLVFIDGQGK LSDVIDVEQL KLPGATLSLD EDLKVFTGAL
KLAHKELRVS VKIGPTTFQV MHTDRAKVLS HWVLLNDIYY ASEIEDVCLL DDNSFVLTIS
IESVPLTIAH NDCDSIVQNI IHIRNRWVLS QPDSVSVHSK IRPKDVPGTL LNMALLNLGS
PDPNLRTAAY NHLCALTATF GLKIEGQLLE TSGICIPSNN TIFIKHLSET LAANDPHLTL
EFLKECLQGF RASTIELKHL CLEYMTPWLS NLVRFYKPRD EGGKRQKQVT DILDDLITLT
VQETEMYPSI QAKIWSTIGM LPELIDVVLD IFLQRSARYG LGSPETARSA EIMADTAVAL
ASGNVQLVAK KLINKVCRIV DKTCMSPTSQ LEQHVRWSDI AILARYLLML SFNNCLDVGK
HLPYIFHTVT LLVCSGSLTM RASTHGLVIN SIHSLCTCSS PSFSEDTHRI LRMSLDEFSL
PKFYLLFGIS KVKSAAGTAF YEHPKSSCKH ANGCEKWLSS ERSAHGTQDK ERLYLTSLEV
ITDALLEIME ACMRDIPKCD WLKTWTLLAK NFAFCLNPAL QPRALIVFGC ISKSITDQDM
RQLLKILMKA LESFNDINLI EAIVMCLTRL QPLLRPESPI HRYLFWIATS VLELDEASLY
ASGLALLEQN LHTLDSQGTF DEKTLEYVMM TTREPLEYQF KQLDHAVGLS FKSNFHFALV
GHLLKGYRHR TPTTVTRTVR VLTMLLAIVA KPSKRDKFEV TPESIPYLTA LVAVSEEVRS
RCHIRHSLDK SLHDSSGSSD VLDTLPSRTT DMPGASNPTS RRQKTWDLLD QSALTQAKQQ
KQSAQRSLSV PSAKDDKSAD NAEQQRDRST RVSLSNENNV LLDPEVLTDF STQTLVLTML
ATLVKYSTNE NETRILYEYL AEATVVFPKV FPVVHNLLDA KINSVLSSCH DQAILNAVQT
IIQNMIACED TNQQHHLQHY LQSCGFRGLW RFAGPYPDSD STQMVSNCTP ESAELFVNCL
RAMVEMCLMM QESNSKETVI GKSKRAGSCQ SDFASKTRPP AGIVQEQSRV STEIDASSVH
VNHIMKEIYR LIFYFTEPRT RLFRVIAVTC SVSLVQCRPH HDNEPTEVEV DESYVFEERY
FISISDIAIL TFFLSLTFSA FRRDSAFINI ENDLRYISVS STTSIAYVRY FLHNCTYNLL
TDSIMVAIRY IYSEESQWSI ENQPREDRSQ FFHYIEILTI RRFYCKRIYR IYRLRFIFKR
SVVKHRKQLL FYLRKNLYET SFDAPYQV
//
