ID A0A4S2KTP4_9HYME Unreviewed; 967 AA.
AC A0A4S2KTP4;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=PRKR-like endoplasmic reticulum kinase {ECO:0000256|ARBA:ARBA00041500};
GN ORFNames=DBV15_09180 {ECO:0000313|EMBL:TGZ51398.1};
OS Temnothorax longispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300112 {ECO:0000313|EMBL:TGZ51398.1, ECO:0000313|Proteomes:UP000310200};
RN [1] {ECO:0000313|EMBL:TGZ51398.1, ECO:0000313|Proteomes:UP000310200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:TGZ51398.1};
RX PubMed=30967075;
RA Kaur R., Stoldt M., Jongepier E., Feldmeyer B., Menzel F.,
RA Bornberg-Bauer E., Foitzik S.;
RT "Ant behaviour and brain gene expression of defending hosts depend on the
RT ecological success of the intruding social parasite.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 374:20180192-20180192(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ51398.1}.
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DR EMBL; QBLH01001684; TGZ51398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S2KTP4; -.
DR STRING; 300112.A0A4S2KTP4; -.
DR Proteomes; UP000310200; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProt.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:UniProt.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11042:SF91; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE; 1.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Initiation factor {ECO:0000313|EMBL:TGZ51398.1};
KW Kinase {ECO:0000313|EMBL:TGZ51398.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:TGZ51398.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000310200};
KW Signal {ECO:0000256|SAM:SignalP};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000313|EMBL:TGZ51398.1};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..967
FT /note="PRKR-like endoplasmic reticulum kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020972279"
FT DOMAIN 497..926
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 658..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 526
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 967 AA; 110805 MW; 1335CF3928190F1D CRC64;
MSRLCQQICL YCTVLITLAC FLVSAEDTLN LCGKQLKKNE RSLVFVNTLD GKISALDANN
HGKILWTKDF NNGPMLSSSI HRRELNNNGQ WVRLIPSLYG GLYKFDGENL ETVPVSADQL
LHSSFRYSDD LVFSGGKELY SYGVSPNTGE ILYQCNVSGC KNNTDRQDYV ELDVLVIQRF
QQTVRAVEAR TGNERWNFSV GQYDLELVPP DVFCPNEVVA SDMEIKVVIP EGLIWAVNKS
NPTVTLWKYK FSSPIVAIWR EDASQISITP GALEKINLFN SSQWEWGSDS AVGPGLYLGM
HERQLYVQEN HNHKNSMYVQ HIKYPWQPYP AAITAVTDTL ADNNNNDEVS IIEANEAQNA
IALSVLYNSE YINEYDYEYR IIDMDKFMIM NSYVHSNSDT LYITEKSMLN YTQKEDNAQI
TQPLWHWWRE ILIFAFTTAL LLNFMSTRRL LKARTTTTNV LLPPLIVERQ IETKRSDSTN
DDSENVNNFK SHYLTDFEPV DCLGKGGYGV VFEARNKIDD CNYAIKRIAL SNSQDSRDRV
LREVKALAKL DHHNIVRYFH AWLECPPSGW QEEHDQQWID KLKCSTDFLS ETTQTETKPN
SVYIDVSQTD QSSIESANED LEFNNMDAND DSYITFERSN ERQDANSFCI NNCSTDTSDL
SSSSSITEKE LPNVNETDHS ESIVFEETDN NTAAKETAKD TAAATRRKRQ KSFFLDLNKM
PNTQKSAKMF LYIQMQLCQR LSLREWLKQH TSRDFSRVLN IFQQIVDAVE YVHLQGLIHR
DLKPSNIFFA YDDKIKIGDF GLVTAMTEGY DRAHTPAAEN ETVSLKNNVH TACVGTHLYM
SPEQINGKIY NYKVDIYSLG IIFFELLTPF FTDMERIVAL SNLKKSIFPK DFAENYPAEY
NLLKMMLDED PINRPTTLGI KAKPPLQNYE KVSLNIDPDS KWHFELPQLT RHSSVTSSNS
SNELPEK
//
