ID A0A4S2L249_9HYME Unreviewed; 476 AA.
AC A0A4S2L249;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:TGZ56631.1};
DE Flags: Fragment;
GN ORFNames=DBV15_12523 {ECO:0000313|EMBL:TGZ56631.1};
OS Temnothorax longispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300112 {ECO:0000313|EMBL:TGZ56631.1, ECO:0000313|Proteomes:UP000310200};
RN [1] {ECO:0000313|EMBL:TGZ56631.1, ECO:0000313|Proteomes:UP000310200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:TGZ56631.1};
RX PubMed=30967075;
RA Kaur R., Stoldt M., Jongepier E., Feldmeyer B., Menzel F.,
RA Bornberg-Bauer E., Foitzik S.;
RT "Ant behaviour and brain gene expression of defending hosts depend on the
RT ecological success of the intruding social parasite.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 374:20180192-20180192(2019).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ56631.1}.
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DR EMBL; QBLH01000312; TGZ56631.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S2L249; -.
DR STRING; 300112.A0A4S2L249; -.
DR Proteomes; UP000310200; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000310200};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 3..130
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 167..339
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 350..471
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT NON_TER 476
FT /evidence="ECO:0000313|EMBL:TGZ56631.1"
SQ SEQUENCE 476 AA; 55713 MW; 696D4F1514B2D017 CRC64;
MKILLISDSK TDISIAAINV NIGSKHDPDD LPGLAHLCEH MLHMGTEEYP QQNNFAEYVS
QSGGRINADT HFKFTSYYFN IIPKKLKGAL DRFAQFFIAP FFRKDLIEKE INNIHSEYNE
RLTDDEWRFE QALVKLSIKP DHPYSKLNIG NKKTLNETPK KDNIDVKDRL KKFYEKYYSA
NIMSLCILSK DGLNNLKNMV IKRFRNVKNK ELPVYSGCPF KDDDFNTVWL HVPIGYIRKL
DVTFAFSEKR EDQMSLKYIK HLLRHKSEGS LLSALKAKSL CNNIEAGDYP VDTNIHFFKV
KFHLTKKGLE DSTDIVEIMF QYINMLKKNE PKKLIYDVIK IQQMSDINNR YNEKIHCLSV
DDISKITCCM QECPMKEIFS KQRAWQSYLI KDLIKEYFTP QNIRIYIATK ACESETDERE
EWYNIKYFKG KIPEGHMKSF NRAADAADSS TELKLPLKNT FIPMKFDIKN ETNKII
//
