ID A0A4S2L5F6_OPIFE Unreviewed; 4137 AA.
AC A0A4S2L5F6;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CRM22_009919 {ECO:0000313|EMBL:TGZ57486.1};
OS Opisthorchis felineus.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=147828 {ECO:0000313|EMBL:TGZ57486.1, ECO:0000313|Proteomes:UP000308267};
RN [1] {ECO:0000313|EMBL:TGZ57486.1, ECO:0000313|Proteomes:UP000308267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK-0245 {ECO:0000313|EMBL:TGZ57486.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TGZ57486.1};
RX PubMed=31117933; DOI=10.1186/s12864-019-5752-8;
RA Ershov N.I., Mordvinov V.A., Prokhortchouk E.B., Pakharukova M.Y.,
RA Gunbin K.V., Ustyantsev K., Genaev M.A., Blinov A.G., Mazur A.,
RA Boulygina E., Tsygankova S., Khrameeva E., Chekanov N., Fan G., Xiao A.,
RA Zhang H., Xu X., Yang H., Solovyev V., Lee S.M., Liu X., Afonnikov D.A.,
RA Skryabin K.G.;
RT "New insights from Opisthorchis felineus genome: update on genomics of the
RT epidemiologically important liver flukes.";
RL BMC Genomics 20:399-399(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ57486.1}.
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DR EMBL; SJOL01009432; TGZ57486.1; -; Genomic_DNA.
DR STRING; 147828.A0A4S2L5F6; -.
DR Proteomes; UP000308267; Unassembled WGS sequence.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000308267}.
FT DOMAIN 2101..2336
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 2545..2706
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 853..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3180..3255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3274..3300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3665..3697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3812..3877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4118..4137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3180..3216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3819..3842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3858..3876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4122..4137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4137 AA; 450842 MW; 53C6B9244688E86E CRC64;
MAEKKPNEWV QLLLLRFDSQ LPIRTGLHTA QSTQNMEQNK ECLITVSKCK FSLVVSGLTK
MLQNIDSMQV YGPDAERNFC DSLLIVLETL EKCLTCQTRE TSRLDETILV KNLLQELFRV
RNLVLNFMNL TSDNVKMYNQ LLTLVSQVLY ALSTQYFNAV FNRILSCLTL AAQDESSGDL
ANELELIQHL NLDVRKLSRL IFEICNRFRS LKKAIWLHLA VYLERAIWNW LENYPQEFDE
LQKRPSDELA ECCERLFYLF TSLCAESGRK KLFVWPLQMM LLVLCPKILE EIINAENGAP
LSPQHQKKKQ FVDEVRKALS THGHGGGSSK PVITEAALLA AVNLCKASSY ININDRNNVL
FVLVHSVYAD LQNLLFNPAK PYIRNSQNLA ETEALLTEFF VASFRITPHN KNLLKVCLQT
SSPAIYHTVL VSALYRIITQ PRLSWWPDVS PFYSKSTEIR TMFLETLNRV NHNPPLRIAQ
CLTFRDKMNL KNKDKTEDSL MGKYNLLLNM VRLINANPLL MLYCPQSRPS TDAQKATFEL
MNGLMSLIQQ STMTELAQEA MDALLCLHQP ANIRLWNLHS PAQAFWEISP QLLYSIAQKL
INRNIPNSCD VLKWLREILI CRVNFLQQNC DCINFPGSAP GANKSDTPTS GGDTGFPLTE
PNIPPCTKTS PVMQVTSCGA AATSAEACQA FTVPSKQSGV DTTGISSQST PTTELNPLLG
PLSVNSKRNR MALIKLETVF FTYLWSLDLE TVLTSMSCFR LLCQEAELWS NAAAAAVFAS
LSDADRSALL GCDFCPSLSF PRSGFSDWDS KSGLVQSNSG LTSGSADVEV KSNDLLRQFS
PQQMSDKLSA TFSYASPRSS QRGIRQADSG RNRGQASGPC IALCSCGCPL CTPSYLPVCT
PGEDHSGTDS FLRDMTFCST DNDNKDYLFP SCSDGSSTSP THTVLGKTGT CPTMAQLPFT
ECGLPDLLPV YSVYAEIADH SRSIVTTGRA HLQKQIWCLL RKVNHQTQGN KLSWEHTYMI
WLRSTKFLIN YPKSKVSGSA STTDDSCYDV ATNHPTSSVG TSSLSSNVGS SGVLGDSSSI
ATELDSIAIP AEYAREGSAP ISGATGSLYA SAASLLGSAG IGLVGSSMNG YSGASVSNTT
RYLAVKRRVS QQSTATDHEI EDVLNEWANM TGFLCALGSV ALSSTPTQPS NLSVPPVNSS
HYCVHCHCRY FSDLGLRPAS RSPRGDETQS ACGPQESERP VESLTISMAN NTVDKPMINS
SANIHETSRL PSPTVASPSL GAQHSLNAHR LTRDFSAMTC LPQQISNSQS PHSTDAVSRN
VGSGMSSPAK AQKTPLTADG ARLAACPHLR PCLHQNSYAS GGLFNRMCAN AVLEEFSRGS
KSCPVYSLGG VESSSRRTSL VQPPSCNQEH HFSPVAQYIG NLLLLISCQH EKFGHKIQKH
VKEAIGNELN PLIYPILFGQ LRAHVDACFS GQGQQQVVVT ETNTLFIENV IFIMRSILDK
QSGKSLDRLN GHLEAVSIES LMLNIVRYVR HLECVHSLQI KIKVCQLVQK MMARREDLSF
RQEMRFRNKL VDYLCDWVMG SSYHLNLATP SNYAAHLTPA ATGPSQPLGV GSSGQASAFT
GSCGSVTGVA GTHGQFTLLG PGGYVLSGVN IPGLAGVSGS IGSGCNLVLT GPIANIPTTV
HTGIASPIIS GTPLVSIPLH IETLGLPCGM NSVHTTEQGT SVPPNAFNVD NYGRAFGSGH
QLIESTSVSV TNQVTPAQGP LAGTSAGQTG FLLLMNSSSA VDALSMASDG HTTGALGTIS
LSGQLGALPV SSVSSTTSFG GDGGGAVAQP LGLVSAVGNA GKLHTLPLLA GSIGASTAGH
INVIPQTQGV GSGAPCPSTI SAGSGPSSEP SPGIQVAGSG ASISVNAQAS GSVYGSTCGT
GSAPGGTTGL TSQAAMQTRE LDLACMEAVA ALLQGMPLQP EEVDRGDLMD AKSHLFAKYF
TLFMNLLNDV ADDREKRAEV RQNNTALRNV TVQAMSNLLN ANIESGLVHA IGLGYHRDPQ
SRAAFMEVLT KILQQGTEFE TLAETALAER YERLIGLVTM VGENGELPIA MALTQVVQGA
SMDELAKVLV TLFDAKNLLY QLFWNVFSKE LEAADSTHTL LRGNSMSSKI MNYCFKHFGH
DFLQSALGPA LMELVRRDAG GSNSFPEMTS FDVVSNNVRT ITVESDNFSA DRAGTNKPSY
EVDPRRLQPG EILEENQKNL TYATELLYGR LISSIDSFPV ALRILCNCLY KLISHYCCTP
DKSDQAATVL STIVFLRFIN PAVVSPCENG LLDFEPPPRV KRGLTLVGKL MQNIANQLLF
TKEPHMRVFD SLLQKHFESC RLFFREIVTS DANYEMPHFN SSPVHHGRPQ HAAASFTDLQ
DTQLAPAAPV LLSNPWVSTN TASSFSPTRS ITTESSVTVG TLVPTFDRPN TGGGGGTVGV
TGFISDDLIH AVHRLLWVNQ GKIGDYLASS RDRKAVGRQP FDRMVTLLAH LGPPEHKSMD
STWNYMEAHS TRLEDCVLRG YQFRDSEEFK RLKSLNIFYQ AGTSRFGNPV FYYIARRYKS
QDYQRVEYPL IICLVSVTLD AYRSKPFELV VDFTHTSVEN RFKNDLLNKW ASIIGPVLRE
YLVAAYIYNC NSWVREYTKI HDRFFSPIKG SRKLVFIDHP TRLNDFIDPD QQRLPGGTLA
LEEDLRVFNN ALKLSHKDTK VAIKVCTNAI QVTSTEKSKV LGHSVILNDV YYASEIEEVC
LVDDNQFTLT ISNDNGPLSF IHDACDSIVQ AIIHIRTRWA LSQPDTHAMH TKIRPRDVPG
TLLNIALLNL GSSDPSLRSA AYNLLCALTQ TFNLKIEGQL LETNGLCIPG NNTLFISEIS
KRLAQLEPHL TLEFLDECIQ GFSRSSIEMK HLCLEYITPW LRNLTRFCRS DDVKQQKVLS
IIDKLITLTI DEEQMYPSIQ TKIWGNLGQV PQLVGLVLDS FIQRSVSCGL GSLQAEIMAD
TSVALAAANV QLVSKKVLSK LCRFIEKTCS APTTLLEHHP LWPEIAPMLR YLLMLSFNNC
IDIRTHLPRL FHIATLLVCT GPLSLRASMH GFVINVIHSL CTSALAKQLS DKTVQQLRQL
LAEFTLPKFY EVFGIQHCKC APISAFPHFR PGERSGLVVS GTVSQPLVVP LTHALSAGAT
ANAPTAPSNQ TGRGSISSGC STSTSESNTS LPTADNLSKP GALRTGTAAP YATYGPTELR
KKSTASPSNL GPPSIILVDE ETSVDSANRL LHEPCSGTSM DSSRHTAAYS ATHTGPSGGT
IFPLHNQSSR DGFNLITGDT QMRNNPSISS RLVPSESPQF GFLKLPTSTS SCIHPSLTAT
PYGLITTPGS QLAASTEGLD RPERLTLSSL EFLTDTLLEV MSLVIKEVPE FTHWLEQWTN
LARKFAFQNN PALQPRAIIV LGCICKGFTD TDIKQLLRIM SRALESYANE LDMEKDLRHR
TVDTGQAELY LIESIIMCLT RLLPLLPANS ATHLPLFWVA LGVLQLDEVS LYAAGLALLE
QNLLTLDEHG TFEQDSLQTV MMRCREQFIL QYKQMDHAVG LSFRDSFHFA LVGHLLKGFR
HPIPQTVART IRVLNTLLSI VAKPLNRDKY QVTKDSVAYL AALLPVSDEV RKRCRLKFRV
PGTLAGPGEH QSPSLHAHGQ PNSAFGSTAV GGPPPKGCTA ATNNLGDWCG STESLHELTN
SGRHCAQRTP SAVGLLRSLL PSPVTNTVLS SRFTRLRQDN LSNLTLSTNL STDRFSSHAV
DHHGQTYRSF HGRHVEGPRH TLQRQLGFQG MPEGLRSRSI DSCPSTTSTT SGMSIPDQFS
PSSGPFISPP LPAGTLEPEH SASSQQPGSG HSAQLEKKTG DSVLLDPEIL TEEATQALTI
AVLTTLVRYT TDENESRVLY EFLADASMVF PRVFPVIHSL LDSKINYVLT HCHDQKILSA
VQSIIQNVIS SGETSVQQLH YLQSIGFGGL WRFSGHFSKA NQNSEAAQLF VNFLEVLIDS
HLPGEDLRTS YTPVLGLGST SRAGNLSSSS SLSLSSLHGP LGADPVLNSA DAESPVPLSP
TLVAVPCAIP TDRDDAISPE AVSVTQIEHV RDARTEVCDT PAGTGTVHQS PERTLES
//
