ID A0A4S2LPQ1_OPIFE Unreviewed; 2682 AA.
AC A0A4S2LPQ1;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Pericentrin/AKAP-450 centrosomal targeting domain-containing protein {ECO:0000259|Pfam:PF10495};
GN ORFNames=CRM22_005729 {ECO:0000313|EMBL:TGZ65720.1};
OS Opisthorchis felineus.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=147828 {ECO:0000313|EMBL:TGZ65720.1, ECO:0000313|Proteomes:UP000308267};
RN [1] {ECO:0000313|EMBL:TGZ65720.1, ECO:0000313|Proteomes:UP000308267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK-0245 {ECO:0000313|EMBL:TGZ65720.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TGZ65720.1};
RX PubMed=31117933; DOI=10.1186/s12864-019-5752-8;
RA Ershov N.I., Mordvinov V.A., Prokhortchouk E.B., Pakharukova M.Y.,
RA Gunbin K.V., Ustyantsev K., Genaev M.A., Blinov A.G., Mazur A.,
RA Boulygina E., Tsygankova S., Khrameeva E., Chekanov N., Fan G., Xiao A.,
RA Zhang H., Xu X., Yang H., Solovyev V., Lee S.M., Liu X., Afonnikov D.A.,
RA Skryabin K.G.;
RT "New insights from Opisthorchis felineus genome: update on genomics of the
RT epidemiologically important liver flukes.";
RL BMC Genomics 20:399-399(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ65720.1}.
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DR EMBL; SJOL01006479; TGZ65720.1; -; Genomic_DNA.
DR STRING; 147828.A0A4S2LPQ1; -.
DR Proteomes; UP000308267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProt.
DR Gene3D; 1.10.287.1490; -; 1.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR18947:SF28; GIRDIN, ISOFORM A; 1.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000308267}.
FT DOMAIN 2383..2474
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 171..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2080..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2241..2278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2566..2682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 78..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 798..871
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1453..1480
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2143..2177
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 229..244
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2086..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2241..2262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2682 AA; 296235 MW; 4C68915EA2690CE9 CRC64;
MEVIYHDLAS GRDSSLSQVL AAWNTRYEEQ YAVLRSLFPV FGDANVEGVS DNAQLKTNLH
DLTLSELREQ FDEVLQLRAT LMVEVDALQQ IRAELEDSQC VSEVHIQLER ATEENKRLQA
AIRAAHEQIS DLFFNKRVME AEMVALRGDR DRQLAEANER VRMAEKAVVA MTSRIRGPKP
EESAAGDKSS PASAGSAKPF VPFKPVVQRL SNAERTKSYA TLTGMSFDEF DSLDEDDGDN
EDAGQPIDDT PPRPGCPPVQ HSEAIPVSMD SPPKKSSDDV VVFSDDAHGT SENDTKTFVL
DEQPDVPPSP TLSSTPRKSL DLSETGSNRY IETPLLTEAT SDWVTPIVKC REETSASAET
VPKADYLKLL DDLEEVRLEL DSVRREFAAK FEAAALQRRS LVDGYSTTRP TDQGLTEQLH
DLAEKVNAVT PDQPQGGSGS LLPTTAPGAT RMFDWSVSPD QTASSFEIQA DSVKPEDDVK
EETDREDRTP VRTSVATVCT SCLELQAELV TTEVLASTQL KEHTRISDAQ IATLELELHN
LRERLEQDQL RPFTLDSCVQ TEPSVIDGGR EHLAVPVTEI SVPPFPLVRP EGVVRQTIDY
QTEPPDSAST ESDGRASVML KRYSKLSADA ACICLALAQR IASMNQRGVP DGEHSPDTND
DFNTLLNALS GEEQEDSDVD TDSYRSGYKI LACSLARLNH EVERLASVVD TREYGRYGPA
YENVPTANGG YSQDREHEVV ELRTRLSAAL QLLSERLPAD TQKALIATSQ IVESERIQLQ
AELERRMIMF EQSHTSSVAE LESSRRALME QLATAEAENV QLKDQLSVTQ QKLQANDRFI
AEQTEERESE REEFRTELAR LETQLRKTKG ELLAAKLVNG ASVTTEDPVD SVSHNKSLWL
EDSIEASEPK HQDSTHRPQS APRHTMVSRL EQGNSLLGTF NCMCRRTSDV THSRSWALSP
RMTNNNGVFD FQSLSPDSVC TPTAAGGKLC HCTLGDVRSP TWPDDSGTIP TAMAHQESSD
HTAVSLVAAS SSFCQTEPEE ESTENQEVVK TAVALLYLND ASSQTDVELV PLEELLQAQT
RIRHLEENNV SLSPLLPNLD THRRPSWVAE ADDDSATGID CVSRVFMDSS TQTLEAEIDE
NSPELVTKTK RIVRTRTWDA AAAAAFLGQL TLTEEEQEFV SSIVKRERRG TQGNSFSHQE
PLQIELKDQA VNTETWDSPQ PGSEPKPKRR HSLPSLLSTM DDTGVEMSRG MTLFDSVDLD
LLRMSGVVEN FQLQDVASSK SSCVPPHVDS IRSDLQTAEE NRDTTLIHQV TEEESPRLAS
VTLLDRAQSP IEVLVDVQSP SIIAPSLSVT DASCDTRALE IEIIPASDLK ALLEQKDASD
LVLSAMREEI TSLQTHHTDL QTDYNFLQEM LEERECELER FAQDSIALQT RLSAIERELK
ERKDVVLERD EDMFILTEAN ESLTARVREL EETLSKLSTR SFLETGVQPD EDLVGDRIKS
PGPQMIEKEI DATRWNAVEL YVQTDPDPFI ESLITRVKEL ETALETSQSR VVESVEAGLQ
TDPDAVVENL TTKVKALEAR RFEVIPSADV NVQTDTGAVL ISEMGNCDVN QSDIKYAAEQ
SVQTDADQLV ESLSARLKCM EEELNVRTRP YMVDCQIQTE SVVATGDPLV SATAALPAPP
NVVQVGEESD RWDTIVEETS TLHGFNDFGE AELAEVPQTE HVPPCVVPSG PVLATSTPDQ
LSEVTDAISS PVPQIQREDI PVELKTVVQR LRAESLRLFS LSTGFQPTDV SQIPTGNGEQ
PQEALQHQFS VFSDLVRANT SLKNALGQIS QMVEVYEIPT SGSSPYQLTE QKTFSYEHIQ
RLVHCTANAL AADETVWLGL LQLSFEQTAE LVSAVSKPSE AECDGKVVPA QRLVWKAITR
LGDQLSSFIR QEDQYRECLV QAHLVEQRYL SAELHTSVTR GDSLASEINR LTERLNTHKE
ALSRADSLNL RLVNQINNLK ADLANANSDL QAEVIQSEQK QAKLDRLNTQ LTEEQQKSSA
FRTQIENLKS DTDRLEQELR DAKQSLVEAN RAVTVAEKRA ENVEQAADQS RIQSKSVNSA
SFSPEHSSIL DATHGQSAIS SQEVSSISPK DLFNAISRTA TNLAVARHTA NKAERRAREL
EATNKELRLC LAETELRLMP LLVAFTQSPL PSCPVSNANN VRSTTRPLTG VRELYSQLPP
SSRFAELKDV CTRLLSIAST EDQEEDERYG NGCNQSSDHS SDDEDEVTPD NPPITSKAVS
FDPKVSICYS LSGSESHLSP QTPVSRIRVG AERDENQLVG LTKDPLLRIK HVTGSFLTDG
TAQPTSLNVP TVPLANETPN RFSSVTTPEQ TVSLERFRNI HARYLRSESY RRALTFQKRY
LLLLLGGFQY PEEAVVASLG RPDFSVYSDQ ASLAATDSGD GFSPPTVSAP IRRFRAAART
AQVIYRMRHM MNRWRRSGLH SSAPIRPSTG DSLSTIQKPT PALSATTGPA VNTTSRLENL
SSGTPQYFAG PVHSSPLTRF PPHYLNSANT VIPTTTLCLN MPTLTTGSTR TIPSVLPSSH
YSDVGFRSST TQTRPSPTRP SQAQPLSHSM TTGQTRGSYS TTALHHQPNF TKSSPSPLTT
TRPRPSTEHR GTSRLTSARS STGSSVGPSV DTRFRSQRFS FR
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