ID A0A4S2M9G0_OPIFE Unreviewed; 1033 AA.
AC A0A4S2M9G0;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=P-type Ca(2+) transporter {ECO:0000256|ARBA:ARBA00012790};
DE EC=7.2.2.10 {ECO:0000256|ARBA:ARBA00012790};
GN ORFNames=CRM22_003012 {ECO:0000313|EMBL:TGZ70748.1};
OS Opisthorchis felineus.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=147828 {ECO:0000313|EMBL:TGZ70748.1, ECO:0000313|Proteomes:UP000308267};
RN [1] {ECO:0000313|EMBL:TGZ70748.1, ECO:0000313|Proteomes:UP000308267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK-0245 {ECO:0000313|EMBL:TGZ70748.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TGZ70748.1};
RX PubMed=31117933; DOI=10.1186/s12864-019-5752-8;
RA Ershov N.I., Mordvinov V.A., Prokhortchouk E.B., Pakharukova M.Y.,
RA Gunbin K.V., Ustyantsev K., Genaev M.A., Blinov A.G., Mazur A.,
RA Boulygina E., Tsygankova S., Khrameeva E., Chekanov N., Fan G., Xiao A.,
RA Zhang H., Xu X., Yang H., Solovyev V., Lee S.M., Liu X., Afonnikov D.A.,
RA Skryabin K.G.;
RT "New insights from Opisthorchis felineus genome: update on genomics of the
RT epidemiologically important liver flukes.";
RL BMC Genomics 20:399-399(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGZ70748.1}.
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DR EMBL; SJOL01005146; TGZ70748.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S2M9G0; -.
DR Proteomes; UP000308267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 2.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR42861:SF29; SECRETORY PATHWAY CALCIUM ATPASE, ISOFORM G; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000308267};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 74..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 949..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..90
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 1033 AA; 113059 MW; 02DF88EB8C6843A6 CRC64;
MRSTPHNTDY HLCARKAAVT NVGELCQLLQ VNLTMGLDED EVKLRRNVAG PNSFDHKSSD
SLIKRYLEQF KEPMILLLLI SAAVSFLMRQ YDDTVSITAA VCIVVTVAFI QNYRSEKALE
ALKNLMPPKC NCVRNGVLST FLASELVPGD VVFLSMGDRI PADMRLIETV DLRVDESSLT
GETEAVPKMA DTLSSTRSLL VPNGVGPTYN PTLTESKEPL LTSITISSDY TANSPTTDAL
NRLRGCHDLT NIAFMGTLVC CGTAKGVVIA TGEHSEFGEV FRMMQSEEAP RTPLQKNMDR
LGKHLSVISL MIIGSIVIVG LIQRRHFLEL LNIGVSLAVA AIPEGLPIVV TVTLAIGQMR
MAARNAVVRK LPAVETLGCV NVVCADKTGT MTKNEMTVSQ IVSSDLEHYT VQSRLDGLPL
AISSSTPNIH RTFSADSGSV VGPCAESGIP LFRSHSIYPH SRTHSTVDLL PSSSCPIAFQ
RIIEIGSICN NAILQDGKLH GQPTEGALLR LASQFRIGDM RQLYIRLQEW SFSSETKMMM
ISCIRNGQVP STGPVYFAKG AVDRILQKCI YVHKPYSLES STGSQSPSDA VCIDNSPVRS
IDSPYPLTLE HRSAILQEAA SLGLLGLRVL AVAEGSHPEQ LVFHGLVGLL DPPRPGVEAC
VRTLLESGVR VVMITGDSVE TAKAIGGRLF LYREGDCCLS GEEVDQLSLT ALQTRVRNVT
IFYRTGPRHK CKIVKALQHC GLIVAMTGDG VNDAVALKSS DIGVAMGYTG TDVCREAADI
VLLDDNFATI LAAMEEGKSI FHNIRNFVGF QLSTSIAALS LIALSTLLSL PTPLNAMQIL
YINILMDGPP AQSLGVEPPD EMVIKQPPRR SQDPILDRQL MMNVLFAAST ILIGTFGIFW
LELADNHVTP RDTTMTFTCF VLFDMFNALS FRSQKKSIFS LGFTTNRMFL IAVSLSLFGQ
LLVIYFPPLQ KVFQTESLSV SDLLLLVCLS STVFVVSEIR KFFRTPRWNT FKPWGTCHTR
CRNRYLKFGE SMV
//
