ID A0A4S4M9G6_9AGAM Unreviewed; 931 AA.
AC A0A4S4M9G6;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 22-FEB-2023, entry version 11.
DE RecName: Full=Coatomer subunit gamma {ECO:0000256|PIRNR:PIRNR037093};
GN ORFNames=EW146_g1625 {ECO:0000313|EMBL:THH19580.1};
OS Bondarzewia mesenterica.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Russulales; Bondarzewiaceae; Bondarzewia.
OX NCBI_TaxID=1095465 {ECO:0000313|EMBL:THH19580.1, ECO:0000313|Proteomes:UP000310158};
RN [1] {ECO:0000313|EMBL:THH19580.1, ECO:0000313|Proteomes:UP000310158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 108281 {ECO:0000313|EMBL:THH19580.1,
RC ECO:0000313|Proteomes:UP000310158};
RA Buettner E., Kellner H.;
RT "Genome sequencing of the rare red list fungi Bondarzewia mesenterica.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR037093}.
CC -!- SUBUNIT: Oligomeric complex. {ECO:0000256|PIRNR:PIRNR037093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037093}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR037093}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR037093};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR037093}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR037093}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR037093}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR037093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the COPG family. {ECO:0000256|ARBA:ARBA00010720,
CC ECO:0000256|PIRNR:PIRNR037093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THH19580.1}.
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DR EMBL; SGPL01000041; THH19580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S4M9G6; -.
DR Proteomes; UP000310158; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1480; Coatomer, gamma subunit, appendage domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR032154; Coatomer_g_Cpla.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR037067; Coatomer_gsu_app_sf.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10261; COATOMER SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10261:SF0; COATOMER SUBUNIT GAMMA-2; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF16381; Coatomer_g_Cpla; 1.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037093};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR037093};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR037093};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR037093};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037093};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037093};
KW Reference proteome {ECO:0000313|Proteomes:UP000310158};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037093}.
FT DOMAIN 20..574
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 661..813
FT /note="Coatomer gamma subunit appendage Ig-like subdomain"
FT /evidence="ECO:0000259|Pfam:PF08752"
FT DOMAIN 816..929
FT /note="Coatomer subunit gamma C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16381"
FT REGION 623..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 101692 MW; 0393B795FDCBD0E6 CRC64;
MSLASKKEEE GGLNSYYNNK TTILQEARVF NESPISPRKC RALLTRIVYL LYFGESFGTQ
EATTLFFGTT KLFQHKDSAL RQMVYLAIKE LANTAEDVIM VTSSIMKDMQ PNSEVIYRPN
AIRALCRIID PSMVQGVERF FKAAIVDRTP SISSAALVSS YHLFPAAKDV VKRWVNEVQE
AVNAKSSTSF FGSSTPSSYL GFGSSSSSSN SGYSPMPSSS YITQYHALGL LYLIRQQDRM
AVTKMIQQLG GGKSGAGTIL KNPMALCMLI RYAAKVIEED PNVQKQMLDM LEGWLRHKSD
MVNLEAARAI CEMRGVTSAQ LTRSIAVLQL FLSSPKPTLK FAATRTLASL ALTHPTSVAT
CNVDLENLIS DSNRSVATYA ITTLLKTGNE ASVDRLMKQI TGFMSEISDE FKVIIVDAIR
SLCLKFPTKH VSMLGFLSGV LRDEGGYDFK RAVVEAIFDM IKFIGDCKEQ ALSHLCEFIE
DCEFTKLSVR ILHLLGIEGP QAPQPAKYIR FIYNRVVLEN ATVRAAAVSS LAKFGISDDD
SKLHNSVAVL LNRCLDDVDD EVRDRAAMYL KVLDAPPLAE TYIKDDSVFS LSALEAKLVS
YVNDANAADT PFDFSSVPKV SRQQAEQEVA RPSTLDTIGT PSAKKSSPSP PPPTAEETQS
AYLQQLAEVP ELASYGPVLN SSAKPVRLTE SETEYQVSCT KHIFKEHVVF QFNVSNTLPD
TILEQVSVIM QPSTDSGLTE DFIIPLPSLS SSSSSSSPGI VYVSFTRDSP EEFATASFTC
ILKFLSKEVD PSTGEPEEEG YEDEYQLEEV ELSAGGDYIV PSYANFSSEW DRLRGGASAT
ETFSLSAMES IKAACDSIVE ILNMEPLGGS QTPTSTSVHT LQLSGLLTGG GGKVLVRCRM
TFSHGQGVTL ELGVRAEKQE ACKLVLAAIG G
//
