ID A0A4S8HXC1_9BACT Unreviewed; 953 AA.
AC A0A4S8HXC1;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:THU39931.1};
GN ORFNames=FAM09_08540 {ECO:0000313|EMBL:THU39931.1};
OS Niastella caeni.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Niastella.
OX NCBI_TaxID=2569763 {ECO:0000313|EMBL:THU39931.1, ECO:0000313|Proteomes:UP000306918};
RN [1] {ECO:0000313|EMBL:THU39931.1, ECO:0000313|Proteomes:UP000306918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HX-2-15 {ECO:0000313|EMBL:THU39931.1,
RC ECO:0000313|Proteomes:UP000306918};
RA Sheng M.;
RT "Niastella caeni sp. nov., isolated from activated sludge.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THU39931.1}.
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DR EMBL; STFF01000002; THU39931.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S8HXC1; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000306918; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 55..173
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 214..393
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 694..872
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 953 AA; 106574 MW; B28D03A7DC9ACE4A CRC64;
MMYSLRVGTR WLLLLVGILS IEYATAQLNM ESKLPVDAKV KIGKLENGLT YYIRQNKKPE
QKVELRLVLN AGSILEDDDQ QGLAHMAEHM AFNGTTHFKK NDIVSFLQDI GVGFGNDLNA
YTGFDETVYI LPIPTDKPGN LDKGFQVLED WAHNVTYLDD DINGERAIIL EESRLGKGAN
ERIFRKIYPQ LFEGSKYAKR LPIGVDSIIK NFPVNNIRRY YKDWYRPDLM AVVVVGDIEL
AKAEAMVKKH FSRLTNPANA RKREYADVPP YTSSQAMVVT DKEATGYQVA INYPAIKKSP
AVTIGDYRKD LIEQMYVSML NERLQELTQK ENPPFIYGAA DFDSYARGYQ SFNAMAAAGT
GDIQKALNAL AEEIERVKRF GFTADELQRA KKTMLAHYET AFNNRGKTES ADYVEEYMNN
FLVQEPIPGI EKEFEYAKAL LPAIKLDEVN AVSNAFKDQK NLFVYMSGPE SMDTTALPSE
KDLLAIIDAR AKADIKPYEE KAVATTLLSK EPKAGKVIAV TKYPLLGTTD YKLSNGVTVT
LKPTDFKNDQ IIMGATRPGG KNSYGLADKY NAEYMTAVTG AMGVGGFSPT DLSKALAGKT
VNVAPVFTTI SDGFHGTSSV KDLETMFQLT YLQCTAPRGD TALFRAFVQR NKLQFAKISA
NPQAAFVDTL YKTLFGNNPL AQVIVPNSAY FDMISYDRVL AIHKERYGDV SGMHFVFAGS
FKESEIKPLI EKYIASLPAT GKKFTIVDNK VRPISGKKTF VVNKGKEDKS LILAFYSGET
PYNEDMELKA QALSEVLNIR IIEELREKIQ GIYGGGTSAD VGKYPYPNYN FVVQLPCGPE
KVDTLVKAIK KEFSDMVAKG PDTTYLNKVK KQWLEQHKLN VKDNGFWVER LLQYKLQGGN
PDRFVHYEKY VKMLTPKDVQ QAAKLMFDGN EFVAIQMPEN AKGGTGAESK KGF
//
